Susceptibilidad de enterobacterias a piperacilina/tazobactam en un hospital pediátrico de Chile
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2017Metadata
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Rojas de la Vega, Juan
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Susceptibilidad de enterobacterias a piperacilina/tazobactam en un hospital pediátrico de Chile
Abstract
Introduction: Enterobacteriaceae are a group of gram-negative rods that can cause serious infections in humans.
A susceptibility in Klebsiella pneumoniae of 79.4% to piperacillin/tazobactam (PIP/TAZO) is reported in
pediatric hospitals in Chile. There is no published data published to date regarding PIP/TAZO susceptibility to
other Enterobacteriaceae species in this population. Aim: To measure the in vitro PIP/TAZO susceptibility in
Enterobacteriaceae isolates from patients in a pediatric hospital in Chile. Methods: Descriptive and prospective
study of Enterobacteriaceae positive cultures from patients assisting to the “Hospital de niños Roberto del Río”
(HRRIO) between January 2013 and August 2014. PIP/TAZO susceptibility was established by gradient diffusion
method (E-test®) according to the 2014 CLSI standards. Results: 163 cases were included. The average age was 4
years and 15 days. 70.6% were female. 79.7% of samples were urine cultures. PIP/TAZO susceptibility in Enterobacteriaceae
was 95.1% (n = 155). The intermediate susceptibility was 1.8% (n = 3). Discussion: The isolates
studied present high susceptibility to PIP/TAZO. This finding could be explained by the fact that this population
has not been exposed to this antimicrobial therapy and also the low rates for ESBL in pediatric infections.
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Rev Chilena Infectol 2017; 34 (6): 563-569
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