N-acylation of lactams derived from natural 2-benzoxazolinones and 1,4-benzoxazin-3-ones

Abstract

The N-acylation reaction of a series of lactams of biological interest, derived from 2-benzoxazolinones and 1,4-benzoxazin-3-one, with acetic anhydride has been studied. The reaction yields show the same tendency as that observed for AM1 calculated ΔH for the deprotonation reaction of the heterocyclic nitrogen atom.