Synthesis, electrochemical, and spectroscopic studies of novel S-nitrosothiols
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Soulère, Laurent
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Synthesis, electrochemical, and spectroscopic studies of novel S-nitrosothiols
Abstract
A series of S-nitrosothiol compounds, structurally related to the NO-donor S-nitroso-N-acetyl-D,L-penicillamine (SNAP) that contain amidin groups were synthesised by S-nitrosation of the corresponding thiols and characterised. The kinetics of decomposition were investigated and showed that the two adenine-based thionitrites exhibited an unusual stability in aqueous solution compared to SNAP, suggesting that these compounds may complex the traces of free copper ions present in solution, which is known to catalyze the decomposition of thionitrites. The electrochemical behaviour of these compounds and their nitric oxide-releasing potential were studied by means of cyclic voltammetry techniques on mercury and glassy carbon electrodes. © 2001 Elsevier Science Ltd. All rights reserved.
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URI: https://repositorio.uchile.cl/handle/2250/156188
DOI: 10.1016/S0040-4020(01)00694-9
ISSN: 00404020
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Tetrahedron, Volumen 57, Issue 33, 2018, Pages 7173-7180
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