Inhibitory K+ current activated by odorants in toad olfactory neurons
Author
dc.contributor.author
Morales,
Author
dc.contributor.author
Ugarte,
Author
dc.contributor.author
Labarca,
Author
dc.contributor.author
Bacigalupo,
Admission date
dc.date.accessioned
2018-12-20T14:34:24Z
Available date
dc.date.available
2018-12-20T14:34:24Z
Publication date
dc.date.issued
1994
Cita de ítem
dc.identifier.citation
Proceedings of the Royal Society B: Biological Sciences, Volumen 257, Issue 1350, 2018, Pages 235-242
Identifier
dc.identifier.issn
14712970
Identifier
dc.identifier.issn
09628452
Identifier
dc.identifier.other
10.1098/rspb.1994.0120
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/156526
Abstract
dc.description.abstract
Odorant responses of isolated olfactory neurons from the toad Caudiverbera caudiverbera were monitored by using patch-clamp techniques. Depending on the stimulus, the same neuron responded with an increase or a decrease in action potential firing. Odorants that activate the cAMP cascade in olfactory cilia increased electrical activity, caused membrane depolarization, and triggered inward currents. In contrast, odorants that do not activate the cAMP cascade inhibited electrical activity, produced membrane hyperpolarization, and activated outward currents in a dose-dependent fashion. Such currents were carried by K+ and blocked by tetraethylammonium. Similar currents were recorded from Xenopus laevis. Our results suggest that this K+ current is responsible for odorant-induced inhibition of action potential firing in olfactory neurons.