Inhibitory K+ current activated by odorants in toad olfactory neurons
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Morales,
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Inhibitory K+ current activated by odorants in toad olfactory neurons
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Odorant responses of isolated olfactory neurons from the toad Caudiverbera caudiverbera were monitored by using patch-clamp techniques. Depending on the stimulus, the same neuron responded with an increase or a decrease in action potential firing. Odorants that activate the cAMP cascade in olfactory cilia increased electrical activity, caused membrane depolarization, and triggered inward currents. In contrast, odorants that do not activate the cAMP cascade inhibited electrical activity, produced membrane hyperpolarization, and activated outward currents in a dose-dependent fashion. Such currents were carried by K+ and blocked by tetraethylammonium. Similar currents were recorded from Xenopus laevis. Our results suggest that this K+ current is responsible for odorant-induced inhibition of action potential firing in olfactory neurons.
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URI: https://repositorio.uchile.cl/handle/2250/156526
DOI: 10.1098/rspb.1994.0120
ISSN: 14712970
09628452
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Proceedings of the Royal Society B: Biological Sciences, Volumen 257, Issue 1350, 2018, Pages 235-242
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