Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents
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Mosnaim, Aron D.
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Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents
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The chemical structure of phenothiazine provides a most valuable molecular template for the development of agents able to interact with a wide variety of biological processes. Synthetic phenothiazines (with aliphatic, methylpiperazine, piperazine-ethanol, piperazine-ethyl, or piperidine side-chain) and/or phenothiazine-derived agents e.g., thioxanthenes, benzepines, imonostilbenes, tricyclic antidepressants, dimetothiazine, and cyproheptadine have been effective in the treatment of a number of medical conditions with widely different etiology. These include various currently clinically used drugs for their significant antihistamic, antipsychotic, anticholinergic (antiparkinson), antipruritic, and/or antiemetic properties. They are also employed, although to a minor extent, as antidepressants, antispasmodics, analgesics, and antiarrhythemics. Some of these agents are also useful as anti-inflammatory, coronary vasodilator, radioprotective, sedative, antitussive, and skeletal muscle-relax
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URI: https://repositorio.uchile.cl/handle/2250/164166
DOI: 10.1097/01.mjt.0000212897.20458.63
ISSN: 10752765
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American Journal of Therapeutics, Volumen 13, Issue 3, 2018, Pages 261-273
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