α2-Adrenoceptor modulation of long-term potentiation elicited in vivo in rat occipital cortex
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2004Metadata
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Mondaca, Mauricio
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α2-Adrenoceptor modulation of long-term potentiation elicited in vivo in rat occipital cortex
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Pretreatment with the α2-adrenoceptor agonist clonidine (31.25, 62.5, or 125 μg/kg, i.p.) dose-dependently reduced long-term potentiation (LTP) elicited in vivo in the occipital cortex of anesthetized rats, whereas pretreatment with the α2-adrenoceptor antagonist yohimbine (0.133, 0.4, or 1.2 mg/kg, i.p.) increased neocortical LTP in a dose-dependent fashion. These effects could be related to the reported disruptive and facilitatory actions induced on memory formation by pretreatment with α2-adrenoceptor agonists and antagonists, respectively. © 2004 Elsevier B.V. All rights reserved.
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URI: https://repositorio.uchile.cl/handle/2250/164525
DOI: 10.1016/j.brainres.2004.07.020
ISSN: 00068993
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Brain Research, Volumen 1021, Issue 2, 2018, Pages 292-296
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