Structural antitumoral activity relationships of synthetic chalcones
Author
dc.contributor.author
Echeverría, César
Author
dc.contributor.author
Santibáñez, Juan Francisco
Author
dc.contributor.author
Donoso Tauda, Óscar
Author
dc.contributor.author
Escobar, Carlos A.
Author
dc.contributor.author
Ramírez Tagle, Rodrigo
Admission date
dc.date.accessioned
2019-03-11T12:56:53Z
Available date
dc.date.available
2019-03-11T12:56:53Z
Publication date
dc.date.issued
2009
Cita de ítem
dc.identifier.citation
International Journal of Molecular Sciences, 2009, 10, 221-231
Identifier
dc.identifier.issn
14220067
Identifier
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10.3390/ijms10010221
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/164690
Abstract
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Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.