Structural antitumoral activity relationships of synthetic chalcones
Artículo
![Thumbnail](/themes/Mirage2/images/cubierta.jpg)
Open/ Download
Publication date
2009Metadata
Show full item record
Cómo citar
Echeverría, César
Cómo citar
Structural antitumoral activity relationships of synthetic chalcones
Author
Abstract
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.
Indexation
Artículo de publicación SCOPUS
Identifier
URI: https://repositorio.uchile.cl/handle/2250/164690
DOI: 10.3390/ijms10010221
ISSN: 14220067
Quote Item
International Journal of Molecular Sciences, 2009, 10, 221-231
Collections