The identification of two subgroups of obese women with differing endometrial proliferation levels: Potential consequences in the development of endometrial cancer
Artículo
![Thumbnail](/themes/Mirage2/images/cubierta.jpg)
Open/ Download
Publication date
2012Metadata
Show full item record
Cómo citar
Villavicencio, A.
Cómo citar
The identification of two subgroups of obese women with differing endometrial proliferation levels: Potential consequences in the development of endometrial cancer
Author
Abstract
Enhanced endometrial proliferation correlates obesity to type-I (estrogen-dependent) endometrial cancer (EC). Our aim was to distinguish obese women (without EC) with differing endometrial proliferation. Endometrial and blood samples were obtained from normal-weight and obese women without EC. Type-I EC samples were obtained from obese patients. On measuring endometrial proliferation (Ki67 and phosphorylated histone H3 (p-H3)), two groups of obese women without EC were identified: obeseHigh Proliferating (O HP) and obeseLow Proliferating (OLP). Increased Ki67 (88.5%, P<0.001), p-H3 (62.6%, P<0.01), 17Β-estradiol/ progesterone ratio (46.3%, P<0.01) and endometrial estrogen receptor alpha (ERα) (82.2%, P<0.001) were observed in OHP compared with OLP patients. ECs possessed similar ERα and enhanced proliferation as OHP, suggesting that OHP women are at higher risk of type-I EC. OLP women were indistinguishable from normal-weight women regarding these determinants of endometrial proliferat
Indexation
Artículo de publicación SCOPUS
Identifier
URI: https://repositorio.uchile.cl/handle/2250/165614
DOI: 10.1038/ijo.2011.189
ISSN: 03070565
14765497
Quote Item
International Journal of Obesity, Volumen 36, Issue 7, 2018, Pages 1012-1015
Collections