Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study
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2020Metadata
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His, Mathilde
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Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study
Author
- His, Mathilde;
- Biessy, Carine;
- Torres Mejía, Gabriela;
- Ángeles Llerenas, Angélica;
- Alvarado Cabrero, Isabel;
- Sánchez, Gloria Inés;
- Borrero, Mauricio;
- Porras, Carolina;
- Rodríguez, Ana Cecilia;
- Garmendia Miguel, María Luisa;
- Olivier, Magali;
- Porter, Peggy L.;
- Lin, MingGang;
- Gunter, Marc J.;
- Romieu, Isabelle;
- Rinaldi, Sabina;
Abstract
Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20-45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1kg/m(2)=0.93; 95% confidence interval=0.89-0.96; waist circumference (WC): OR per 10cm=0.81 (0.69-0.96); hip circumference (HC): OR per 10cm=0.80 (0.67-0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 <= BMI<25), women with central obesity (WC>88cm) had an increased risk compared to women with normal WC (OR=3.60(1.47-8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10cm=1.38 (0.98-1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.
Patrocinador
World Health Organization
Union for International Cancer Control (UICC)
Pan American Health Organization (PAHO)
Ibero-American Programme for the Development of Science and Technology (CYTED)
Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias
1115-569-348899
Universidad de Antioquia
CPT-1801
SIIU-2019-25272
International Agency for Research on Cancer
Ligue nationale contre le cancer
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Artículo de publicación ISI Artículo de publicación SCOPUS
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Scientific Reports (2020) 10:2294
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