Now showing items 21-40 of 60

    • Jullian Matthaei, Carolina; Alfaro, Muriel; Zapata Torres, Gerald Amilcar; Olea Azar, Claudio (SPRINGER/PLENUM PUBLISHERS, 2010-10)
      The formation of the complexes of galangin (GAL) with native β-cyclodextrin (βCD), and with its substituted counterparts such as dimethyl-βCD (DMβCD) and hydroxypropyl-βCD (HPβCD), was studied by fluorescence spectra in ...
    • Gerpe, Alejandra; Aguirre, Gabriela; Boiani, Lucía; Cerecetto, Hugo; González, Mercedes; Olea Azar, Claudio; Rigol Olsen, Carolina; Maya Arango, Juan; Morello Casté, Antonio; Piro, Oscar E.; Arán, Vicente J.; Azqueta, Amaia; López de Ceráin, Adela; Monge, Antonio; Rojas, María Antonieta; Yaluff, Gloria (PERGAMON-ELSEVIER SCIENCE LTD, 2006-05-15)
      A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the ...
    • Pizarro, Guadalupe del Carmen; Marambio, Oscar G.; Jeria Orell, Manuel; Huerta, Margarita R.; Rodríguez, Oscar O.; Olea Azar, Claudio; Rivas, Bernabé L.; Habicher, W. D. (JOHN WILEY & SONS LTD, 2007-01)
      Chlorophenylmaleimide (Cl-PhMI) and N-maleoylglycine (N-MG) with beta-methylhydrogen itaconate (beta-MHI) were copolymerized by radical polymerization, and their metal ion retention capacity (MRC) and thermal behavior were ...
    • Mendizábal Emaldía, Fernando; Olea Azar, Claudio (JOHN WILEY & SONS INC, 2002-03-15)
      The electronic structures of complexes and one-dimensional metallomacrocycles with cyanide as bridged ligand, such as [MacM(CN)(2)](-) and [MacM(CN)](n) [Mac = phthalocyanine, tetrabenzoporphyrine; M = Co(III), Rh(III)] ...
    • Barriga, Germán; Olea Azar, Claudio; Norambuena, Ester; Castro, Ana; Porcal, Williams; Gerpe, Alejandra; González, Mercedes; Cerecetto, Hugo (ELSEVIER, 2010)
      A new series of heteroaryl nitrones, 1–7, bearing furoxanyl and thiadiazolyl moieties, were evaluated for their free radical-trapping properties. The physicochemical characterization by electron paramagnetic resonance ...
    • Demoro, Bruno; Sarniguet, Cynthia; Sánchez Delgado, Roberto; Rossi, Miriam; Liebowitz, Daniel; Caruso, Francesco; Olea Azar, Claudio; Moreno, Virtudes; Medeiros, Andrea; Comini, Marcelo A.; Otero, Lucía; Gambino, Dinorah (ROYAL SOC CHEMISTRY, 2012)
      In the search for new therapeutic tools against neglected diseases produced by trypanosomatid parasites, and particularly against African Trypanosomiasis, whose etiological agent is Trypanosoma brucei, organoruthenium ...
    • Otero, Lucía; Aguirre, Gabriela; Boiani, Lucía; Denicola, Ana; Rigol Olsen, Carolina; Olea Azar, Claudio; Maya Arango, Juan; Morello Casté, Antonio; González, Mercedes; Gambino, Dinorah; Cerecetto, Hugo (ELSEVIER, 2006-11)
      Rhenium and ruthenium complexes of the type [(ReOCl2)-O-V(PPh3)L] and [(RuC2)-C-II(DMSO)(2)L], where L are 5-nitroftitylsemicarbazone derivatives, were prepared in an effort to obtain new anti-trypanosomal agents combining ...
    • Barriga González, Germán Eduardo; Aliaga, Carolina; Olea Azar, Claudio; Zúniga López, María C.; González, Mercedes; Cerecetto, Hugo (Bentham Science Publishers Ltd., 2017)
      Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the half-lives of the ...
    • Núñez Vergara, Luis; Squella Serrano, Juan; Olea Azar, Claudio; Bollo Dragnic, Soledad; Navarrete Encina, Patricio; Sturm Schaub, Juan (PERGAMON-ELSEVIER SCIENCE, 2000)
      This paper reports both the electrochemical characterization and the reactivity of the nitroso radical anion from nitrosobenzene with glutathione. The reduction of nitrosobenzene to the corresponding nitroso radical anion ...
    • Otero, Lucía; Vieites, Marisol; Boiani, Lucía; Denicola, Ana; Rigol Olsen, Carolina; Opazo, Lucía; Olea Azar, Claudio; Maya Arango, Juan; Morello Casté, Antonio; Krauth Siegel, R. Luise; Piro, Oscar E.; Castellano, Eduardo; González, Mercedes; Gambino, Dinorah; Cerecetto, Hugo (AMER CHEMICAL SOC, 2006-06-01)
      In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel palladium (II) complexes with the ...
    • Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Cerecetto, Hugo; Di Maio, R.; González, Mercedes; Porcal, Williams; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Maya Arango, Juan (BENTHAM SCIENCE PUBL LTD., 2005-06)
      In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic ...
    • Arriagada, C.; Paris Pizarro, Irmgard; Matas, M. J. S. de las; Martínez Alvarado, P.; Cárdenas, S.; Castañeda, P.; Graumann, Rebecca; Pérez Pastene, C.; Olea Azar, Claudio; Couve, E.; Herrero, M. T.; Caviedes Fernández, Pablo; Segura Aguilar, Juan (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004-07)
      Leukoaminochrome o-semiquinone radical is generated during one-electron reduction of dopamine oxidation product aminochrome when DT-diaphorase is inhibited. Incubation of 100 muM aminochrome with 100 muM dicoumarol, an ...
    • Arancibia, Rodrigo; Klahn, A. Hugo; Buono Core, Gonzalo E.; Contreras, Daniel; Barriga, Germán; Olea Azar, Claudio; Lapier, Michel; Maya Arango, Juan; Ibañez, Andrés; Garland, María Teresa (Elsevier, 2013)
      In the search for new therapeutic tools for the treatment of American trypanosomiasis, a series of novel ferrocene and cyrhetrene imine compounds, derived from 5-nitro-heterocycles, were designed, synthesized and ...
    • Norambuena V., Ester; Olea Azar, Claudio; Rufs, A. M.; Encinas, M. V. (ROYAL SOC CHEMISTRY, 2004-03-21)
      The reduction of several nitrobenzenes bearing electron-donor and electron-withdrawing substituents in the 4-position by triethylamine in acetonitrile was studied by cyclic voltammetry, EPR spectroscopy, and steady-state ...
    • Mendizábal Emaldía, Fernando; Olea Azar, Claudio; Briones, Rodolfo (JOHN WILEY & SONS INC, 2001-04-15)
      Electronic structure aspects related to the semiconducting properties of monomers and polymers of phythalocyanoiron with bidentate bridging ligands, PcFe-L-2 and -[PcFe(L)](n), have been investigated from density functional ...
    • Vieites, Marisol; Otero, Lucía; Santos, Diego; Toloza, Jeannette; Figueroa, Roberto; Norambuena, Ester; Olea Azar, Claudio; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Morello Casté, Antonio; Maya Arango, Juan; Garat, Beatriz; Gambino, Dinorah (ELSEVIER SCIENCE INC, 2008-05)
      In the search for new therapeutic tools against Chagas’ disease (American Trypanosomiasis) two series of new platinum(II) complexes with bioactive 5-nitrofuryl containing thiosemicarbazones as ligands were synthesized, ...
    • Marambio, Oscar G.; Pizarro, Guadalupe del Carmen; Jeria Orell, Manuel; Huerta, Margarita R.; Olea Azar, Claudio; Habicher, W. D. (0887-624X, 2005-10-15)
      The free-radical copolymerization of N-phenylmaleimide (N-PhMI) with acrylic acid was studied in the range of 25-75 mol % in the feed. The interactions of these copolymers with Cu(H) and Co(H) ions were investigated as a ...
    • Martínez Alvarado, P.; Dagnino Subiabre, Alexies; Paris Pizarro, Irmgard; Metodiewa, D.; Welch, C. J.; Olea Azar, Claudio; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Segura Aguilar, Juan (ACADEMIC PRESS INC, 2001-05-25)
      The endogenous dopamine-derived neurotoxin salsolinol was found to decrease survival in the dopaminergic neuronal cell line RCSN-3, derived from adult rat substantia nigra in a concentration-dependent manner (208 muM ...
    • Vieites, Marisol; Smircich, Pablo; Parajón Costa, Beatriz; Rodríguez Borges, Jorge; Galaz, Verónica; Olea Azar, Claudio; Otero, Lucía; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Gómez Barrio, Alicia; Garat, Beatriz; Gambino, Dinorah (SPRINGER, 2008-06)
      In the search for new therapeutic tools against Chagas disease (American trypanosomiasis) palladium and platinum complexes of the bioactive ligand pyridine-2- thiol N-oxide were exhaustively characterized and evaluated in ...
    • Díaz Elizondo, Jessica; Chiong Lay, Mario; Rojas Rivera, Diego; Olea Azar, Claudio; Kwon, H. Moo; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2006-12-01)
      Cells have developed compensatory mechanisms to restore cell volume, and the ability to resist osmotic swelling or shrinkage parallels their resistance to necrosis or apoptosis. There are several mechanisms by which cells ...