Browsing by Author "Gai, María Nella"
Now showing items 1-15 of 15
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Gai, María Nella; Costa, Edda; Arancibia, Aquiles (DUSTRI-VERLAG DR KARL FEISTLE, 2009-04)Objective: To evaluate the systemic bioavailability of a new controlled release cyclobenzaprine tablet, and the influence of a high fat meal on its bioavailabillty. Subjects, materials and methods: 24 and 12 healthy male ...
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Tapia Villanueva, Cristián; Escobar, Z.; Costa, Edda; Sapag Hagar, Jaime; Valenzuela Lozano, Fernando; Basualto Flores, Carlos; Gai, María Nella; Yazdani-Pedram Zobeiri, Mehrdad (ELSEVIER SCIENCE BV, 2004-01)The aim of this work was to evaluate the possibility of using mixtures and/or polyelectrolyte complexes from both chitosan-alginate and chitosan-carrageenan as prolonged drug release systems. Different dissolution profiles ...
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Desarrollo de un comprimido de teofilina de liberación controlada. Evaluación "in vitro" e "in vivo" Pezoa, R.; Gai, María Nella; Gutiérrez, C.; Arancibia, Aquiles (Real Academia de Farmacia, 1992)Se desarrollaron las tres formulaciones (F1, F2 y F3) de Teofilina de 300mg de liberación controlada, en forma de comprimidos obtenidos por vía húmeda, utilizando las resinas acrílicas Eudagrit S199R y EUDAGRIT RSPMR. Las ...
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Gai, María Nella; Pezoa, R.; Corbeaux, J.; Arancibia, Aquiles (SOC CHIMICA ITALIANA, 1989-11)A 300 mg controlled-reelase theophylline formulation was developed as a tablet prepared by wet granulation using the acrylic resins Eudagrit S 100R and Eudagrit RSPMR. The tablet was compared with a marketed controlled-release ...
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Gai, María Nella; Thielemann, Ana María; Muñoz, Fernando; Telha Maldonado, Claudio; Chávez, H. (Colegio de Farmacéuticos de la Provincia de Buenos Aires (Argentina), 1993)Se evalúa la biodisponibilidad absoluta de un comprimido de liberación controlada de teofilina desarrollado en nuestro laboratorio, el cual utiliza resinas acrílicas Eudagrit como sistema regulador de la cesión del fármaco ...
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Gai, María Nella; Pinilla Roa, Rosa; Paulos, Claudio; Chávez, Jorge; Puelles, Verónica; Arancibia, Aquiles (PRESTON PUBLICATIONS INC, 2005-04)
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Gai, María Nella; Thielemann, Ana María; Arancibia, Aquiles (DUSTRI-VERLAG DR KARL FEISTLE, 2000-06)Background: Food-induced changes on the bioavailability of a sustained release lithium carbonate matrix tablet, which uses an acrylic matrix of Eudragit RSPM as sustaining agent, have been studied in healthy male volunteers. ...
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Arancibia, Aquiles; Gai, María Nella; Paulos, Claudio; Chávez Arrué, Jorge; Pinilla, E.; Angel, N.; Ritschel, W. A. (DUSTRI-VERLAG DR KARL FEISTLE, 2004-06)Introduction: A cascade of pathophysiological events occurs with the ascension to high altitude (H). We have performed studies on the effects of exposure to H on the pharmacokinetics of drugs. The hypothesis behind these ...
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Gai, María Nella; Isla, A.; Andonaegui, María Teresa; Thielemann, A.; Seitz, Carlos (1997)Food-induced changes on bioavailability of 2 sustained release theophylline matrix tablets, which uses an hydrophilic matrix of Carbopol 974P and lipid matrix of hydrogenated castor oil (Cutina HR) as sustaining agents, ...
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Gai, María Nella; Thielemann, Ana María; Arancibia, Aquiles (DUSTRI-VERLAG DR KARL FEISTLE, 1993-11)Food-induced changes on the bioavailability of a sustained-release theophylline tablet, which uses acrylic resins Eudragit as sustaining agent, were studied in 12 healthy male volunteers. The tablet was developed in our ...
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Andonaegui Álvarez, María Teresa; Barría, J. L.; Thielemann, Ana María; Seitz, C.; Gai, María Nella (MARCEL DEKKER INC, 1999)Dissolution profiles of theophylline (TP) from three types of sustained-release (SR) matrix tablets (plastic [PL], lipid [LP], and hydrophilic [HP]) in different dissolution media, with and without enzymes, were established ...
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Gai, María Nella; Storpirtis, S.; García, P.; Costa, Edda; Thielemann, Ana María; Arancibia, Aquiles (Longman Group, 1992)A lithium carbonate controlled release tablet was evaluated in vivo and compared with a conventional lithium carbonate tablet. Changes in the first formulation were made in order to achieve a better performance. The ...
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Arancibia, Aquiles; Gai, María Nella; Chávez Arrué, Jorge; Paulos, Claudio; Pinilla, E.; González, C.; Villanueva, S.; Ritschel, W. A. (DUSTRI-VERLAG DR KARL FEISTLE, 2005-02)Introduction: The exposure to high altitude (H) produces several physiologic alterations which may induce changes in the pharmacokinetics of drugs. This hypothesis has been confirmed in previous studies which suggest that ...
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Tapia Villanueva, Cristián; Corbalán, V.; Costa, Edda; Gai, María Nella; Yazdani-Pedram Zobeiri, Mehrdad (BIOMACROMOLECULES 6(5):2389-2395, 2005-09)The aim of this work was to establish the diltiazem hydrochloride release mechanism from the chitosan-alginate matrix tablet (MCB/AS) and chitosan-carrageenan matrix tablet (MCS/CSI). The weight loss for MCS/CSI is mainly ...
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Castro, A.; Arancibia, Aquiles; Romero, P.; Gai, María Nella (GOVI-VERLAG GMBH, 2003-10)A validated HPLC method for the determination of ranitidine in human plasma is presented. Sulfanilamide as internal standard (IS) was used. Plasma samples were purified by solid phase extraction (SPE) using a copolymeric ...