Browsing by Author "Maya Arango, Juan"

Now showing items 1-17 of 17

    • Comparative cytotoxicity of alkyl gallates on mouse tumor cell lines and isolated rat hepatocytes 
      Frey, Christian; Pavani, Mario; Cordano, Gianni; Muñoz, Sergio; Rivera, Enrique; Medina, Jorge; Morello Casté, Antonio; Maya Arango, Juan; Ferrada Parker, Jorge (ELSEVIER, 2007)
      Alkyl esters of gallic acid inhibited the respiration rate of mouse sarcoma 786A and mouse mammary adenocarcinoma TA3 cell lines and its multiresistant variant TA3-MTX-R more effectively than gallic acid, both in the ...
    • ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted ... 
      Aguilera, Benjamín; Olea Azar, Claudio; Norambuena, Ester; Arán, Vicente J.; Mendizábal Emaldía, Fernando; Lapier, Michel; Maya Arango, Juan; Kemmerling Weis, Ulrike; López Muñoz, Rodrigo (PERGAMON-ELSEVIER SCIENCE LTD, 2011-03)
      Electrochemical and ESR studies were carried out in this work with the aim of characterizing the reduction mechanisms of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones by means of cyclic voltammetry in DMSO ...
    • Estudio fisicoquímico y biológico de una serie de complejos metálicos con ligandos bioactivos contra ... 
      Toloza González, Jeannette de los Ángeles (Universidad de Chile, 2016)
      Gracias al descubrimiento de las aplicaciones anticancerígenas del cisplatino, el interés por estos compuestos y sus propiedades ha aumentado, dando altas expectativas en la farmacéutica. En esta tesis se propuso que ...
    • Evaluación de la actividad tripanocida de Castanedia santamartensis (Asteraceae) e identificación de ... 
      Quintero Pertuz, Helena (Universidad de Chile, 2022)
      El déficit de tratamientos eficaces para la enfermedad de Chagas ha llevado a la búsqueda de nuevas sustancias con potencial terapéutico. Los productos naturales poseen una gran variedad de motivos estructurales químicos, ...
    • Evaluación de la capacidad antioxidante y actividad tripanocida de nuevos compuestos N-aril amido cumarinas 
      Muñoz Cáceres, Andrea Joana (Universidad de Chile, 2015)
      La Tripanosomiasis americana o mal de Chagas es una enfermedad potencialmente mortal, causada por el parásito protozoario Trypanosoma cruzi (T. cruzi), cuya principal vía de infección es a través de las heces del insecto ...
    • Evaluación de la capacidad antioxidante y tripanocida de nuevos compuestos hidroxilados de cumarinas 
      Robledo O'Ryan, Natalia Carolina (Universidad de Chile, 2015)
      El estrés oxidativo es causado por un desequilibrio entre la producción de especies reactivas de oxígeno (radicales libres) y una disminución en los antioxidantes. Con el tiempo, este desajuste en el equilibrio entre ...
    • Facing Chagas' Disease: Trypanocidal Properties of New Coumarin-chalcone Scaffolds 
      Vázquez Rodríguez, Saleta; Guinez, Roberto; Matos, María; Olea Azar, Claudio; Maya Arango, Juan; Uriarte, Eugenio; Santana, Lourdes (Bentham Science, 2016)
      With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds was tested against the epimastigote, ...
    • Ferrocenyl and cyrhetrenyl azines containing a 5-nitroheterocyclic moiety: Synthesis, structural characterization, ... 
      Gómez, Johana; Klahn, A. Hugo; Fuentealba, Mauricio; Sierra, Diego; Olea Azar, Claudio; Maya Arango, Juan; Medina, Manuela E. (Elsevier, 2017)
      The synthesis of unsymmetrical ferrocenyl and cyrhetrenyl azines [(h5-C5H4)-CR¼N-N¼CH-2-C4H2X-5-NO2]M (M¼Re(CO)3, Fe(h5-C5H5); R¼H, CH3,X¼O, S) has led to the development of new derivativesof 5-nitroheterocycles as potential ...
    • Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of ... 
      Gerpe, Alejandra; Aguirre, Gabriela; Boiani, Lucía; Cerecetto, Hugo; González, Mercedes; Olea Azar, Claudio; Rigol Olsen, Carolina; Maya Arango, Juan; Morello Casté, Antonio; Piro, Oscar E.; Arán, Vicente J.; Azqueta, Amaia; López de Ceráin, Adela; Monge, Antonio; Rojas, María Antonieta; Yaluff, Gloria (PERGAMON-ELSEVIER SCIENCE LTD, 2006-05-15)
      A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the ...
    • New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents 
      Rodríguez Arce, Esteban; Putzu, Eugenia; Lapier, Michel; Maya Arango, Juan; Olea Azar, Claudio; Echeverría, Gustavo A.; Piro, Oscar E.; Medeiros, Andrea; Sardi, Florencia; Comini, Marcelo; Risi, Gastón; Salinas, Gustavo; Correia, Isabel; Pessoa, João Costa; Otero, Lucía (Royal Society of Chemistry, 2019)
      In the search for a more effective chemotherapy for the treatment of Chagas' disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic ...
    • Nitrofurylsemicarbazone rhenium and ruthenium complexes as anti-trypanosomal agents 
      Otero, Lucía; Aguirre, Gabriela; Boiani, Lucía; Denicola, Ana; Rigol Olsen, Carolina; Olea Azar, Claudio; Maya Arango, Juan; Morello Casté, Antonio; González, Mercedes; Gambino, Dinorah; Cerecetto, Hugo (ELSEVIER, 2006-11)
      Rhenium and ruthenium complexes of the type [(ReOCl2)-O-V(PPh3)L] and [(RuC2)-C-II(DMSO)(2)L], where L are 5-nitroftitylsemicarbazone derivatives, were prepared in an effort to obtain new anti-trypanosomal agents combining ...
    • Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox ... 
      Otero, Lucía; Vieites, Marisol; Boiani, Lucía; Denicola, Ana; Rigol Olsen, Carolina; Opazo, Lucía; Olea Azar, Claudio; Maya Arango, Juan; Morello Casté, Antonio; Krauth Siegel, R. Luise; Piro, Oscar E.; Castellano, Eduardo; González, Mercedes; Gambino, Dinorah; Cerecetto, Hugo (AMER CHEMICAL SOC, 2006-06-01)
      In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel palladium (II) complexes with the ...
    • Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Cerecetto, Hugo; Di Maio, R.; González, Mercedes; Porcal, Williams; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Maya Arango, Juan (BENTHAM SCIENCE PUBL LTD., 2005-06)
      In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic ...
    • Novel ruthenium(II) cyclopentadienyl thiosemicarbazone compounds with antiproliferative activity on pathogenic ... 
      Fernández, Mariana; Rodríguez Arce, Esteban; Sarniguet, Cynthia; Morais, Tânia S.; Tomaz, Ana Isabel; Olea Azar, Claudio; Figueroa, Roberto; Maya Arango, Juan; Medeiros, Andrea; Comini, Marcelo; Garcia, M. Helena; Otero, Lucía; Gambino, Dinorah (Elsevier, 2015)
      Searching for new prospective antitrypanosomal agents, three novel Ru(II)-cyclopentadienyl compounds, [Ru(eta(5)-C5H5)(PPh3)L], with HL = bioactive 5-nitrofuryl containing thiosemicarbazones were synthesized and characterized ...
    • Platinum(II) metal complexes as potential anti-Trypanosoma cruzi agents 
      Vieites, Marisol; Otero, Lucía; Santos, Diego; Toloza, Jeannette; Figueroa, Roberto; Norambuena, Ester; Olea Azar, Claudio; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Morello Casté, Antonio; Maya Arango, Juan; Garat, Beatriz; Gambino, Dinorah (ELSEVIER SCIENCE INC, 2008-05)
      In the search for new therapeutic tools against Chagas’ disease (American Trypanosomiasis) two series of new platinum(II) complexes with bioactive 5-nitrofuryl containing thiosemicarbazones as ligands were synthesized, ...
    • Resolvina D1 gatillada por aspirina limita el progreso de la cardiomiopatía chagásica crónica, regulando ... 
      Carrillo Werner, Ileana Vanessa (Universidad de Chile, 2022)
      La enfermedad de Chagas, causada por el protozoario Trypanosoma cruzi, es endémica en América Latina y está ampliamente distribuida en todo el mundo debido a la migración poblacional. Clínicamente, se caracteriza por una ...
    • Simvastatina induce la reparación cardíaca a través de la activación de la vía de notch 1 en la cardiomiopatía ... 
      Guzmán Rivera, Daniela Inés (Universidad de Chile, 2020)
      La enfermedad de Chagas es una parasitosis causada por el protozoo Trypanosoma cruzi. Es endémica en Latinoamérica, pero por la migración poblacional, hay casos reportados en Europa, Japón y Australia, entre otros países. ...