Browsing by Author "f0295a9b-5595-4e10-8cfe-98f0765104e3"
Now showing items 1-20 of 54
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Hidalgo Tapia, María Cecilia; Carrasco, M. Angélica; Muñoz, Pablo; Núñez González, Marco (2007)A great body of experimental evidence collected over many years indicates that calcium has a central role in a variety of neuronal functions. In particular, calcium participates in synaptic plasticity, a neuronal process ...
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Arias Cavieres, Alejandra; Adasme, Tatiana; Sánchez, Gina; Muñoz, Pablo; Hidalgo Tapia, María Cecilia (Frontiers Research Foundation, 2017)© 2017 Arias-Cavieres, Adasme, Sánchez, Muñoz and Hidalgo.Recognition memory comprises recollection judgment and familiarity, two different processes that engage the hippocampus and the perirhinal cortex, respectively. ...
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Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco Friz, María Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (MARY ANN LIEBERT INC, 2011-04)Soluble amyloid beta-peptide oligomers (A beta Os), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and synaptic function. Here, we report that A beta Os at ...
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Paula-Lima, Andrea; Hidalgo Tapia, María Cecilia (2013)
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Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco, M. Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (2011)Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca2+ homeostasis and synaptic function. Here, we report that AβOs at sublethal concentrations ...
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Lobos, Pedro; Bruna, Barbara; Cordova, Alex; Barattini, Pablo; Galáz, Jose Luis; Adasme, Tatiana; Hidalgo Tapia, María Cecilia; Muñoz, Pablo; Paula Lima, Andrea (Hindawi Limited, 2016)© 2016 Pedro Lobos et al.Increased reactive oxygen species (ROS) generation and the ensuing oxidative stress contribute to Alzheimer's disease pathology. We reported previously that amyloid-β peptide oligomers (AβOs) produce ...
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Calcium dependence of ryanodine-sensitive calcium channels from brain cortex endoplasmic reticulum Marengo Olivares, Juan José; Bull Simpfendorfer, Ricardo; Hidalgo Tapia, María Cecilia (Elsevier B.V., 1996)Endoplasmic reticulum vesicles isolated from rat brain cortex and fused with lipid bilayers displayed ryanodine-sensitive calcium channels, with three cytoplasmic calcium dependences. A: Channels (n = 5) stimulated by Ca2+ ...
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Kemmerling Weis, Ulrike; Muñoz Dimitrov, Pablo; Müller, Marioly; Sánchez, Gina; Aylwin Ostale, María de la Luz; Klann, Eric; Carrasco Friz, María Angélica; Hidalgo Tapia, María Cecilia (2007)Hydrogen peroxide, which stimulates ERK phosphorylation and synaptic plasticity in hippocampal neurons, has also been shown to stimulate calcium release in muscle cells by promoting ryanodine receptor redox modification ...
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More, Jamileth Y.; Bruna, Barbara A.; Lobos, Pedro; Galaz, Jose L.; Figueroa, Paula L.; Namias, Silvia; Sánchez, Gina; Barrientos Briones, Genaro; Valdes Guerrero, Jose; Paula Lima, Andrea; Hidalgo Tapia, María Cecilia; Adasme, Tatiana (Mary Ann Liebert Inc publishers, 2018)Aims: Previous studies indicate that hippocampal synaptic plasticity and spatial memory processes entail calcium release from intracellular stores mediated by ryanodine receptor (RyR) channels. In particular, RyR-mediated ...
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Hidalgo Tapia, María Cecilia (Lippincott Williams and Wilkins, 2017)
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Hidalgo Tapia, María Cecilia; Núñez González, Marco (2007)Calcium and iron play dual roles in neuronal function: they are both essential but when present in excess they cause neuronal damage and may even induce neuronal death. Calcium signals are required for synaptic plasticity, ...
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Hidalgo Tapia, María Cecilia; Arias Cavieres, Alejandra (American Physiological Society, 2016-05)In this review article, we address how activity-dependent Ca2+ signaling is crucial for hippocampal synaptic/structural plasticity and discuss how changes in neuronal oxidative state affect Ca2+ signaling and synaptic ...
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Kamp, Frits; Donoso Laurent, Paulina; Hidalgo Tapia, María Cecilia (Biophysical Society, 1998)Fast (milliseconds) Ca2+ release from sarcoplasmic reticulum is an essential step in muscle contraction. To electrically compensate the charge deficit generated by calcium release, concomitant fluxes of other ions are ...
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Paula-Lima, Andrea C.; Adasme, Tatiana; Hidalgo Tapia, María Cecilia (Mary Ann Liebert Inc., 2014)Significance: Memory is an essential human cognitive function. Consequently, to unravel the cellular and molecular mechanisms responsible for the synaptic plasticity events underlying memory formation, storage and loss ...
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Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)Studies done many years ago established unequivocally the key role of calcium as a universal second messenger. In contrast, the second messenger roles of reactive oxygen and nitrogen species have emerged only recently. ...
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Férez, Claudio F.; Marengo, Juan José; Bull Simpfendorfer, Ricardo; Hidalgo Tapia, María Cecilia (1998)Adenosine 5'-cyclic diphosphoribose [cyclic ADP-ribose (cADPR)], a metabolite of NAD+ that promotes Ca2+ release from sea urchin egg homogenates and microsomal fractions, has been proposed to act as an endogenous agonist ...
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Rojas, Eduardo; Hidalgo Tapia, María Cecilia (1968)Labelled Ca `,+ were incorporated into giant axons froln the squid Dosidicus gigas by immersing them in sea water containing 4'5Ca'-' ~. The washout technique was used and two kinetics for 4SCa2+ outflow were demonstrated ...
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Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Humeres, Alexis; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (AMER PHYSIOLOGICAL SOC, 2007-07)Despite their relevance for neuronal Ca2+-induced Ca2+ release (CICR), activation by Ca2+ of ryanodine receptor (RyR) channels of brain endoplasmic reticulum at the [ ATP], [Mg2+], and redox conditions present in neurons ...
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Sánchez, Gina; Escobar, Matías; Pedrozo Cibils, Zully; Macho Fisher, Pilar; Domenech Lira, Raúl; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)Aim: Our objective was to investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct ...
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Beltrán, Marianela; Barrientos, Genaro; Hidalgo Tapia, María Cecilia (SOCIEDAD BIOLOGIA CHILE, 2006)We measured the kinetics of calcium dissociation from calsequestrin in solution or forming part of isolated junctional sarcoplasmic reticulum membranes by mixing calsequestrin equilibrated with calcium with calcium-free ...