Now showing items 1834-1853 of 2801

    • Navarro, Paola; Chiong Lay, Mario; Volkwein, Karen; Moraga, Francisco; Ocaranza, María Paz; Jalil Milad, Jorge; Sun, Woo Lim; Jeong-Ah, Kim; H., Moo Kwon; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-07-25)
      Changes in cardiac osmolarity occur in myocardial infarction. Osmoregulatory mechanisms may, therefore, play a crucial role in cardiomyocyte survival. Tonicity-responsive enhancer binding protein (TonEBP) is a key ...
    • Arias Carrasco, Raúl Rubén; Giddaluru, Jeevan; Cardozo, Lucas E.; Martins Moraes, Felipe; Maracaja Coutinho, Vinicius; Nakaya, Helder I. (Sociedad de Biología de Chile, 2021)
      The current COVID-19 pandemic has already claimed more than 3.7 million victims and it will cause more deaths in the coming months. Tools that track the number and locations of cases are critical for surveillance and help ...
    • Hoare, Anilei; Bittner, Mauricio; Carter, Javier; Álvarez Armijo, Sergio Aníbal; Zaldívar San Román, María Mercedes; Bravo, Denisse; Valvano, Miguel A.; Contreras, Inés (AMER SOC MICROBIOLOGY, 2006-03)
      Salmonella enterica serovar Typhi causes typhoid fever in humans. Central to the pathogenicity of serovar Typhi is its capacity to invade intestinal epithelial cells. The role of lipopolysaccharide (LPS) in the invasion ...
    • Amweg, A. N.; Salvetti, N. R.; Stangaferro, M. L.; Paredes Vargas, Alfonso; Lara, H. H.; Rodríguez, F. M.; Ortega, H. H. (Elsevier, 2013)
      Cystic ovarian disease (COD) is an important cause of infertility in cattle, and ACTH has been involved in regulatory mechanisms related to ovarian function associated with ovulation, steroidogenesis, and luteal function. ...
    • Montenegro-Nicolini, Miguel; Morales, Javier O. (Springer New York LLC, 2017)
      © 2016, American Association of Pharmaceutical Scientists.The main route of administration for drug products is the oral route, yet biologics are initially developed as injectables due to their limited stability through ...
    • Faggion, Clovis Mariano; Diaz, Karla Tatiana (Elsevier USA, 2019)
      Objectives: To report systematic review definitions that are published in overviews of reviews and to propose a new classification of systematic reviews. Study Design and Setting: In this review of overviews, we searched ...
    • Sobarzo Sánchez, Eduardo; Cassels Niven, Bruce; Saitz Barría, Claudio; Jullian Matthaei, Carolina (JOHN WILEY & SONS LTD, 2001-06)
      The novel heterocycles 1,11-dimethoxy-2-hydroxy-6-methyloxazolo[4,5-k]-5,6,6a,7-tetrahydro-4H-dibenzo [de,g]quinoline, 1,12-dimethoxy-2-hydroxy-6-methyl-9-phenyl-10H-oxazin[5,6-k]-5,6,6a,7-tetrahydro-4H-dibenzo ...
    • Calero, Rolando; Vega, Andrés; García, Ana María; Spodine Spiridonova, Evgenia; Manzur Saffie, Jorge (2003)
      The oxidation product of the binuclear copper (I) complex Cu2L(CIO4)2 (L = N,N′-bis-(6-methyl-2-pyridil) (2′-pyridyl)methyl m-xylylidene imine) has been isolated and structurally characterised. In the cupric species, ...
    • Manzur Saffie, Jorge; Garcia, A. M.; Rivas, V.; Atria Salas, Ana María; Valenzuela, J.; Spodine Spiridonova, Evgenia (Elsevier Ltd, 1997)
      Copper(II) complexes of the ligands (6-methyl-2,2′-dipyridyl)methane (MeDPM) and (6,6′-dimethyl-2,2′-dipyridyl)methane (diMeDPM) were prepared and used as catalysts for the oxidation of 3,5-ditert-butylcatechol to ...
    • Salazar González, Ricardo Andrés; Navarrete Encina, Patricio; Camargo Grandón, Rodrigo; Squella Serrano, Juan; Núñez Vergara, Luis (ELECTROCHEMICAL SOC INC, 2008)
      Electrochemical oxidation of 4-(3-indolyl)- and 4-(5-indolyl)-1,4-dihydropyridines (DHPs) in aprotic and protic media is reported. Also, the reactivity of compounds toward alkylperoxyl radicals 2,2'-azobis-(2-amidinopropane) ...
    • Núñez Vergara, Luis; Salazar González, Ricardo Andrés; Camargo Grandón, Rodrigo; Carbajo, J.; Conde, B.; Navarrete Encina, Patricio; Squella Serrano, Juan (PERGAMON-ELSEVIER SCIENCE, 2007-06-15)
      This work reports the electrochemical oxidation of three newly synthesized C4-hydroxyphenyl-substituted 1,4-dihydropyridine derivatives in dimethylsulfoxide. The reactivity of the compounds with ABAP-derived alkylperoxyl ...
    • Ortíz Yáñez, María Eugenia; Núñez Vergara, Luis; Camargo Grandón, Rodrigo; Squella Serrano, Juan (KLUWER ACADEMIC/PLENUM PUBL, 2004-03)
      The final pyridine derivatives were separated and identified by gas chromatography/ mass spectrometry (GC-MS). The intermediates, anion dihydropyridine and the HO2./HO2- species, were observed from voltammetric studies and ...
    • Klein, Andres; Maldonado, Carola; Vargas, Lina M.; Gonzalez, Marcela; Robledo, Fermín; Perez de Arce, Karen; Muñoz, Francisco J.; Hetz Flores, Claudio; Alvarez, Alejandra R.; Zanlungo, Silvana (2011)
      Niemann-Pick type C (NPC) is a neurodegenerative disease characterized by the intralysosomal accumulation of cholesterol leading to neuronal apoptosis. We have previously reported the activation of the c-Abl/p73 proapoptotic ...
    • Díaz Araya, Guillermo; Nettle Danniels, Maurice; Castro Agüero, Pablo; Miranda, Fernando; Greig, Douglas; Campos Bastidas, Ximena; Chiong Lay, Mario; Nazal N., Carolina; Corbalán, Ramón; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2002-02)
      Objective: To evaluate the oxidative stress status and the modification with glucose-insulin-potassium (GIK) therapy in patients with acute myocardial infarction undergoing primary percutaneous transluminal coronary ...
    • Morales, Cyndi R.; Pedrozo Cibils, Zully; Lavandero González, Sergio; Hill, Joseph A. (Mary Ann Liebert, 2014)
      Significance: Autophagy is an evolutionarily ancient process of intracellular protein and organelle recycling required to maintain cellular homeostasis in the face of a wide variety of stresses. Dysregulation of reactive ...
    • Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Chiong Lay, Mario; Díaz Araya, Guillermo; Mellado, Rose Marie; Rojas, Diego; Concepción, Roberto; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2007-08)
      Despite advances in treatment, chronic heart failure still is associated with a pool- prognosis and remains a leading cause of cardiovascular death. Cumulatingi evidence sugigest,; that imbalances in redox state lead to a ...
    • Rodríguez Arce, Esteban; Cancino Rivera, Patricio; Arias Calderón, Manuel; Silva Matus, Paul; Saldías, Marianela (MDPI, 2020)
      Cancer is a disease that involves impaired genome stability with a high mortality index globally. Since its discovery, many have searched for effective treatment, assessing different molecules for their anticancer activity. ...
    • Diaz, S.; Camilión, C.; Deferrari, G.; Fuenzalida, H.; Armstrong, R.; Booth, C.; Paladini, A.; Cabrera, S.; Casiccia, C.; Lovengreen, C.; Pedroni, J.; Rosales, A.; Zagarese, H.; Vernet, M. (2006)
      Ozone and UV radiation were analyzed at eight stations from tropical to sub-Antarctic regions in South America. Ground UV irradiances were measured by multichannel radiometers as part of the Inter American Institute for ...
    • Hernández Cáceres, María Paz; Cereceda, Karina; Hernández, Sergio; Li, Ying; Narro, Carla; Rivera, Patricia; Silva, Patricio; Ávalos, Yenniffer; Jara, Claudia; Burgos, Paulina; Toledo Valenzuela, Lilian; Lagos, Pablo; Cifuentes Araneda, Flavia; Pérez Leighton, Claudio; Bertocchi, Cristina; Clegg, Deborah J.; Criollo Céspedes, Alfredo; Tapia Rojas, Cheril; Burgos, Patricia V.; Morselli, Eugenia (Taylor & Francis, 2020)
      High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed ...
    • Seelenfreund, D.; Clarke, A. C.; Oyanedel, N.; Piña, R.; Lobos, S.; Matisoo-Smith, E. A.; Seelenfreund, A. (2010)
      Paper mulberry (Broussonetia papyrifera (L.) Vent.) was one of the most widely distributed crop species in prehistoric Oceania, occurring from continental East Asia to the Polynesian islands. Its broad distribution is ...