Browsing by Subject "6-Hydroxydopamine"

Now showing items 1-6 of 6

    • Aminochrome as a preclinical experimental model to study degeneration of dopaminergic neurons in Parkinson's ... 
      Paris Pizarro, Irmgard; Cardenas, Sergio; Lozano, Jorge; Pérez Pastene, Carolina; Graumann, Rebecca; Riveros, Alejandra; Caviedes, Pablo; Segura Aguilar, Juan (2007)
      Four decades after L-dopa introduction to PD therapy, the cause of Parkinson's disease (PD) remains unknown despite the intensive research and the discovery of a number of gene mutations and delections in the pathogenesis ...
    • Lesion of the bulbospinal noradrenergic pathways blocks desipramine-induced inhibition of the C-fiber evoked ... 
      Hernández, Alejandro; Laurido, Claudio; Mondaca, Mauricio; Pelissier Serrano, Teresa; Burgos, Hector; Soto Moyano, Rubén (2001)
      Desipramine-induced inhibition of spinal cord nociceptive transmission was studied in rats with or without lesion of the bulbospinal noradrenergic system by recording the C-fiber evoked nociceptive reflex from a hind limb. ...
    • Neurotoxin Mechanisms and Processes Relevant to Parkinson’s Disease: An Update 
      Segura Aguilar, Juan; Kostrzewa, Richard M. (Springer, 2015)
      The molecular mechanism responsible for degenerative process in the nigrostriatal dopaminergic system in Parkinson's disease (PD) remains unknown. One major advance in this field has been the discovery of several genes ...
    • Neurotoxins and neurotoxicity mechanisms. An overview 
      Segura Aguilar, Juan; Kostrzewa, Richard M. (Springer New York LLC, 2006)
      Neurotoxlns represent unique chemical tools, providing a means to 1) gain insight into cellular mechanisms of apopotosis and necrosis, 2) achieve a morphological template for studies otherwise unattainable, 3) specifically ...
    • Neurotoxins as Preclinical Models for Parkinson’s Disease 
      Segura Aguilar, Juan (Springer New York LLC, 2018)
      © 2018, Springer Science+Business Media, LLC, part of Springer Nature.Translational medicine is one of the major concerns in this century. While significant advances have been made with scientific knowledge, the translation ...
    • One-electron reduction of 6-hydroxydopamine quinone is essential in 6-hydroxydopamine neurotoxicity 
      Villa, Monica; Muñoz, Patricia; Ahumada-Castro, Ulises; Paris, Irmgard; Jiménez, Ana; Martínez, Isabel; Sevilla, Francisca; Segura Aguilar, Juan (2013)
      6-Hydroxydamine has widely been used as neurotoxin in preclinical studies related on the neurodegenerative process of dopaminergic neurons in Parkinson's disease based on its ability to be neurotoxic as a consequence of ...