Browsing by Subject "DNA repair"

Now showing items 1-3 of 3

    • A Flap Endonuclease (TcFEN1) Is Involved in Trypanosoma cruzi Cell Proliferation, DNA Repair, and Parasite Survival 
      Ponce, Iván; Aldunate, Carmen; Valenzuela, Lucía; Sepúlveda Contreras, Sofía; Garrido, Gilda; Kemmerling Weis, Ulrike; Cabrera Vallejos, Gonzalo; Galanti Garrone, Norbel (Wiley, 2017)
      FLAP endonucleases (FEN) are involved both in DNA replication and repair by processing DNA intermediaries presenting a nucleotide flap using its phosphodiesterase activity. In spite of these important functions in DNA ...
    • Characterization of Trypanosoma cruzi MutY DNA glycosylase ortholog and its role in oxidative stress response 
      Kunrath Lima, Marianna; Marçal Repolês, Bruno; Alves, Ceres Luciana; Furtado, Carolina; Andrade Rajao, Matheus; Macedo, Andrea Mara; Franco, Gloria Regina; Junho Pena, Sergio Danilo; Valenzuela, Lucía; Wisnovsky, Simon; Kelley, Shana O.; Galanti Garrone, Norbel; Cabrera Vallejos, Gonzalo; Machado, Carlos Renato (Elsevier, 2017)
      Trypanosoma cruzi is a protozoan parasite and the causative agent of Chagas disease. Like most living organisms, it is susceptible to oxidative stress, and must adapt to distinct environments. Hence, DNA repair is essential ...
    • Expression, purification, and biochemical characterization of recombinant DNA polymerase beta of the ... 
      Maldonado Maldonado, Edio; Rojas, Diego A.; Moreira Ramos, Sandra; Urbina, Fabiola; Miralles, Vicente J.; Solari Illescas, Aldo; Venegas Hermosilla, Juan Antonio (Springer, 2015)
      Chagas disease, caused by the protozoan Trypanosoma cruzi, is a major parasitic disease that affects millions of people in America. However, despite the high impact of this disease on human health, no effective and ...