Now showing items 1-2 of 2

    • Deficits in spatial memory correlate with modified γ-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus 

      Tretter, Verena; Revilla-Sanchez, Raquel; Houston, Catriona; Terunuma, Miho; Havekes, Robbert; Florian, Cédrick; Jurd, Rachel; Vithlani, Mansi; Michels, Guido; Couve, Andrés; Sieghart, Werner; Brandon, Nicholas; Abel, Ted; Smart, Trevor G.; Moss, Stephen J. (2009)
      Fast synaptic inhibition in the brain is largely mediated by γ-aminobutyric acid receptors (GABAAR). While the pharmacological manipulation of GABAAR function by therapeutic agents, such as benzodiazepines can have profound ...
    • Synthesis and GABAA receptor activity of oxygen-bridged neurosteroid analogs 

      Alvarez, Lautaro D.; Veleiro, Adriana S.; Baggio, Ricardo; Garland, María Teresa; Edelsztein, Valeria C.; Coirini, Héctor; Burton, Gerardo (2008)
      Three analogs of neuroactive steroids were prepared (4-6) in which 1,11- or 11,19-oxygen bridges give a constrained conformation. Their 3D structures were obtained by ab initio calculations and in the case of 3α-hydroxy- ...