Browsing by Subject "Heart"
Now showing items 1-15 of 15
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(2012)Increasing evidence indicates that endoplasmic reticulum (ER) stress is involved in various diseases. In the human heart, ischemia/reperfusion has been correlated to ER stress, and several markers of the unfolded protein ...
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(Frontiers Media, 2021)RNA splicing has been recognized in recent years as a pivotal player in heart development and disease. The Ca2C/calmodulin dependent protein kinase II delta (CaMKIId) is a multifunctional Ser/Thr kinase family and generates ...
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(2011)In vivo chemiluminescence (CL) is a measure of reactive oxygen species in tissues. CL was used to assess pulmonary and cardiac responses to inhaled aerosols derived from aged emissions of three coal-fired power plants in ...
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(2011)Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Although treatments have improved, development of novel therapies for patients with CVD remains a major research goal. Apoptosis, ...
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(2012)Kinins mediate their cellular effects through B1 (B1R) and B2 (B2R) receptors, and the activation of B2R reduces collagen synthesis in cardiac fibroblasts (CF). However, the question of whether B1R and/or B2R have a role ...
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(European Respiratory Soc Journals Ltd, 2021)Background Pulmonary hypertension (PH) is a frequent complication in patients with COPD. Objective To determine if, in patients with COPD, the presence of PH decreases exercise tolerance. Methods We included studies that ...
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(1997)This study was performed to evaluate the effects on mechanical and metabolic function of endogenous endothelin-1 on post-ischaemic myocardial stunning. Isolated rat hearts were given BQ-123 (710 nM) or vehicle alone before ...
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FK866 compromises mitochondrial metabolism and adaptive stress responses in cultured cardiomyocytes (Elsevier, 2015)Aim: FK866 is an inhibitor of the NAD(+) synthesis rate-limiting enzyme nicotinamide phosphoribosyltransferase (NAMPT). Using FK866 to target NAD(+) synthesis has been proposed as a treatment for inflammatory diseases and ...
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(Elsevier Science BV, 2018)The L-type calcium channel (LTCC) is an important determinant of cardiac contractility. Therefore, changes in LTCC activity or protein levels could be expected to affect cardiac function. Several studies describing LTCC ...
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(MDPI, 2018)More than 140 million people live and works (in a chronic or intermittent form) above 2500 m worldwide and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated that 55,000 persons work in high ...
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(Springer New York LLC, 2017)© 2017, Springer International Publishing AG. The heart must function continuously as it is responsible for both supplying oxygen and nutrients throughout the entire body, as well as for the transport of waste products to ...
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(Lippincott Williams and Wilkins, 2015)Autophagy is a catabolic recycling pathway triggered by various intra- or extracellular stimuli that is conserved from yeast to mammals. During autophagy diverse cytosolic constituents are enveloped by double-membrane ...
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(Elsevier, 2018-05)Aims: Considerable evidence points to critical roles of intracellular Ca2+ homeostasis in the modulation and control of autophagic activity. Yet, underlying molecular mechanisms remain unknown. Mutations in the gene (pkd2) ...
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(Hindawi Ltd, 2018)Alterations in cardiac energy metabolism play a key role in the pathogenesis of diabetic cardiomyopathy. Hypercholesterolemia associated with bioenergetic impairment and oxidative stress has not been well characterized in ...
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(2011)Several clinical trials have shown the beneficial effects of statins in the prevention of coronary heart disease. Additionally, statins promote apoptosis in vascular smooth muscle cells, in renal tubular epithelial cells ...
