Now showing items 1-19 of 19

    • Gómez Mesa, Juan Esteban; Gutiérrez Posso, Juliana María; Escalante Forero, Manuela; Córdoba Melo, Brayan Daniel; Cárdenas Marín, Paula Andrea; Perna, Eduardo R.; Valle Ramos, Mádelyn Raquel; Giraldo González, Germán Camilo; Flórez Alarcón, Noel Alberto; Rodríguez Caballero, Ida Fabiola; Núñez Carrizo, Cristian; Cabral Gueyraud, Luz Teresa; Marte Arias, Sara Raquel; Hardin, Elizabeth Ashley; Álvarez Sangabriel, Amanda; Menjívar de Ramos, María Eugenia; Van der Hilst, Kwame; Cruz Díaz, Licurgo Jacob; Fausto Ovando, Sergio Roberto; Rodríguez, Luis Arturo; Escalante, Juan Pablo; Ormaechea Gorricho, Gabriela; Bornancini, Norberto Raúl; Rodríguez González, María Juliana; Campbell Quintero, Sebastián; González Hormostay, Raquel E.; Oviedo Pereira, Guillermo; Trout Guardiola, Guillermo; Encina, Juan Justiniano; Jerez Castro, Ana Margarita; Drazner, Mark; Quesada Chaves, Daniel; Romero Guerra, Alexander; Rossel Mariángel, Víctor; Speranza, Mario (Wiley, 2024)
      Background: About 80% of cardiovascular diseases (including heart failure [HF]) occur in low‐income and developing countries. However, most clinical trials are conducted in developed countries. Hypothesis: The American ...
    • Nemchenko, Andriy; Chiong Lay, Mario; Turer, Aslan; Lavandero González, Sergio; Hill, Joseph A. (2011)
      The epidemic of heart failure continues apace, and development of novel therapies with clinical efficacy has lagged. Now, important insights into the molecular circuitry of cardiovascular autophagy have raised the prospect ...
    • Parra, Valentina; Rothermel, Beverly A. (Academic Press, 2017)
      © 2016 Elsevier LtdThe calcium-activated protein phosphatase, calcineurin, lies at the intersection of protein phosphorylation and calcium signaling cascades, where it provides an essential nodal point for coordination ...
    • Mazzucco Vezzera, Guillermo Andres; Pilon, Leonardo; Escalante, Juan Pablo; Chichizola, Nicolás; Torres Castro, Rodrigo Hernán (Cureus Inc, 2021)
      The treatment of choice for patients with advanced heart failure (HF) and with limiting symptoms with evidence of a poor prognosis despite optimal conventional treatment is a heart transplant. However, there is little ...
    • Hameau, Rene; Gabrielli, Luigi; Garrido, Marcelo; Guzmán, Ana María; Retamal, Ignacio; Vacarezza, María José; Greig, Douglas; Ocqueteau, Mauricio; Sánchez, César; Pizarro, Marcela; Corvalán, Alejandro; Lavandero González, Sergio; Castro, Pablo F.; Martínez, Gonzalo (Sociedad Medica de Santiago, 2018)
      © 2018, Sociedad Medica de Santiago. All rights reserved. Recently, we have witnessed major improvements in cancer treatment. Early diagnosis and development of new therapies have reduced cancer-related mortality. However, ...
    • Speranza, Mario; Saldarriaga, Clara; Ramos, Carlos E.; Quesada, Daniel; Rossel Mariángel, Víctor; Ventura Umanzor, Jaime R.; Pow-Chon, Freddy; Alarco, Walter; Figueroa, Yolanda; Magaña, Antonio; Gómez Mesa, Juan E.; Rodríguez García, David (Permanyer, 2023)
      La insuficiencia cardiaca (IC) es un evento significativo para la salud pública. Tiene una prevalencia entre el 1 y 2%, tasa de mortalidad entre el 7 y 17% y de hospitalización entre el 32 y 44%. Esto implica un riesgo a ...
    • Speranza, Mario; Gómez Mesa, Juan E.; Fairman, Enrique; Rossel Mariángel, Víctor; Fernández, Felipe N.; Saldarriaga, Clara; Pow-Chon, Freddy; Quesada, Daniel; Ramos, Carlos E.; Rodríguez, Iris; Jerez, Ana; Chávez, Adolfo; Núñez, Elaine; Pereda, Maximiliano; Chazzin, Gerardo; Sosa Liprandi, María I.; Romero, Alexander (Instituto Nacional de Cardiología Ignacio Chávez, 2023)
      La insuficiencia cardíaca (IC) es una patología que afecta al 1% de la población y se encuentra acompañada de deficiencia de hierro como comorbilidad en el 50% de los casos. La anemia, por su parte, está presente en el ...
    • Díaz-Toro, Felipe; Nazzal Nazal, Carolina; Verdejo, Hugo; Rossel, Víctor; Castro, Pablo; Larrea, Ricardo; Concepción, Roberto; Sepúlveda, Luis; Sepúlveda, Luis (Sociedad Medica de Santiago, 2017)
      © 2017 Rev Med Chile. All right reserved. Background: Frailty is a geriatric syndrome characterized by a progressive impairment in the subjects’ ability to respond to environmental stress. Frailty is more commonly found ...
    • Rossel Mariángel, Víctor; Díaz Toro, Felipe; Verdejo, Hugo; Concepción, Roberto; Sepúlveda, Luis; Castro, Pablo; Vukasovic, José Luis; Bernales, Angie; Bernales, Angie (Sociedad Medica de Santiago, 2017)
      Background: Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF). Aim: To measure Gal-3 at the moment of discharge in patients ...
    • Castro, Pablo; Gabrielli, Luigi; Verdejo, Hugo; Greig, Douglas; Mellado, Rosemarie; Concepción, Roberto; Sepulveda, Luis; Vukasovic, José Luis; García Nannig, Lorena; Pizarro, Marcela; Pivet, Deisy; Carrillo, Constanza; Tapia, Fabiola; Navarro, Mario; Troncoso, Rodrigo; Baraon (2010)
      It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the ...
    • Castro, Pablo; Verdejo, Hugo; Altamirano, Rodrigo; Downey, Patricio; Vukasovic, José Luis; Sepúlveda Jaqui, Luis; Lanas, Fernando; Bilbao, Paola; Pacheco, Ricardo; Rossel Mariángel, Víctor (Sociedad Médica de Santiago, 2013)
      Background: Acute deterioration of kidney function among patients admitted to the hospital for cardiac failure is associated with an increased mortality. Aim: To investigate the association between deterioration of kidney ...
    • Greig, Douglas; Castro, Pablo; Gabrielli, Luigi; Miranda, Rodrigo; Verdejo, Hugo; Alcaíno Gálvez, Hernán Alejandro; Bustos, Carlos; Chiong Lay, Mario; Godoy, Iván; Mellado, Rosemarie; García Nannig, Lorena; Salas, Daniela; Vivar, Raúl; Vukasovic, José Luis; Concepción, Roberto; Díaz Araya, Guillermo (2008)
      Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. ...
    • Moraga, Francisco; Troncoso, Rodrigo; Mellado, Rosemarie; Díaz Araya, Guillermo; Vukasovic, José Luis; Greig, Douglas; Pérez, Osvaldo; García Nannig, Lorena; Roldán, Juan; Ocaranza, María Paz; Jalil Milad, Jorge; Chiong Lay, Mario; Castro, Pablo (2008)
      Background: ß adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostasis. Among these, ß1 and ß2 AR regulate cardiac contractility and frequency and are important pharmacological ...
    • Bartolucci, Jorge; Verdugo, Fernando J.; Carrion, Flavio; Abarzúa, Ema; Goset, Carlos; Lamich, Rubén; Sanhueza, Patricio; Pedreros, Pablo; Nazzal, Carolina; Khoury, Maroun; Figueroa, Fernando E. (Sociedad Medica de Santiago, 2015)
      © 2015, Sociedad Medica de Santiago. All rights reserved. Background: Intracoronary delivery of autologous bone marrow mononuclear cells is an interesting therapeutic promise for patients with heart failure of different ...
    • Kuzmicic, Jovan; Del Campo, Andrea; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Bravo Sagua, Roberto; Hechenleitner, Jonathan; Zepeda, Ramiro; Castro, Pablo F.; Verdejo, Hugo; Parra, Valentina; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...
    • Winter, José Luis; Castro, Pablo; Meneses, Luis; Chalhub, Mónica; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Chiong Lay, Mario; Concepción, Roberto; Mellado, Rosemarie; Hernández, Claudia; Uribe, Sergio; Lavandero González, Sergio (2010)
      Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by ...
    • Rossel, Víctor; Duarte, Manuel; Muñoz, Pilar; Bravo, Catherine; Bobadilla, Gustavo; Verdugo, Fernando; Guardamagna, Carmen (Sociedad Medica de Santiago, 2019)
      © 2019, Sociedad Medica de Santiago. All rights reserved.Background: Pharmacological treatment improves survival in patients with heart failure with reduced ejection fraction. The use of sacubutril/valsartan and ivabradine ...
    • Rossel Mariángel, Víctor; Díaz, Rodrigo; Merello, Lorenzo; Aránguiz Santander, Ernesto; Stockins, Aleck; Olivares, Gabriel (Sociedad Médica de Santiago, 2018)
      There has been a progressive increase in the use of mechanical circulatory support in our country in the last years, mainly in the short-term: as a bridge to cardiac transplant or recovery, which has allowed to rescue ...
    • Alcaíno Gálvez, Hernán Alejandro; Greig, Douglas; Castro, Pablo; Verdejo, Hugo; Mellado, Rosemarie; García Nannig, Lorena; Díaz Araya, Guillermo; Quiroga, Clara; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart ...