Browsing by Subject "Liver"

Now showing items 1-17 of 17

    • Antimetastatic effect of Celecoxib/PLGA in a TA3-MTX-R murine breast adenocarcinoma model Efecto antimetastásico ... 
      Roa Henríquez, Ignacio; Moraga, José; Cantín, Mario; Rosas, Carlos; Lemus, David (Universidad de la Frontera, 2015)
      © 2015, Universidad de la Frontera. All rights reserved.Metastasis is the propagation process of a cancerous focus to an organ other than that in which it started; usually occurring through blood or lymphatic route. The ...
    • Brain and liver lipid peroxidation levels following acute and short-term lindane administration in the rat 
      Arisi, Ana Carolina M.; Kiyoko, Simizu; Marisa, Kogake; Barny, Afonso C.D.; Silva, Marcia A.S.; Barros, Silvia B.M.; Boveris, Alberto; Videla Cabrera, Luis; Junqueira, Virginia (1994)
      Oxidative stress-related parameters in rat brain and liver were evaluated following acute (60 mg/kg i.p., 2 and 24 h after dosing) or short-term (1000 ppm in the diet for 90 days) lindane administration. Both treatments ...
    • Chemiluminescent and respiratory responses related to thyroid hormone-induced liver oxidative stress 
      Fernández Arancibia, Virginia; Llesuy, Susana; Solari, L.; Kipreos, Katina; Videla Cabrera, Luis; Boveris, A. (Informa Healthcare, 1988)
      Chemiluminescent and respiratory responses were studied in the liver of rats treated with 0.1 mg of triiodothyronine (T)/kg for I to 7 days. Hyperthyroidism resulted in significant increments in the spontaneous chemiluminescence ...
    • Damage Control in Penetrating Liver Trauma: fear of the Unknown 
      Ordóñez, Carlos A.; Parra, Michael W.; Millán, Mauricio; Caicedo, Yaset; Guzmán Rodríguez, Mónica; Padilla, Natalia; Salamea Molina, Juan Carlos; García, Alberto; González Hadad, Adolfo; Fernando Pino, Luis; Herrera, Mario Alain; Rodríguez Holguín, Fernando; Serna, José; Salcedo, Alexander; Aristizábal, Gonzalo; Orlas, Claudia; Ferrada, Ricardo; Scalea, Thomas; Ivatury, Rao (Médica Valle, Colombia, 2020)
      The liver is the most commonly affected solid organ in cases of abdominal trauma. Management of penetrating liver trauma is a challenge for surgeons but with the introduction of the concept of damage control surgery ...
    • Effect of ethanol and iron on the hepatic and biliary levels of glutathione and lipid peroxidative indexes 
      Videla Cabrera, Luis; Fernández Arancibia, Virginia; Valenzuela Bonomo, Carlos (1985)
      Data presented here indicate that iron exposure exacerbates the changes in the glutathione status of the liver cell and the lipid peroxidative response of the tissue induced by acute ethanol intoxication. In these conditions, ...
    • Glucose turnover rate and peripheral insulin sensitivity in alcoholic patients without liver damage 
      Bunout Barnett, Daniel; Petermann, Margarita; Bravo, Roberto; Kelly,; Hirsch Birn, Sandra; Ugarte,; Ilurriaga, (1989)
      Glucose intolerance is frequently found in alcoholic patients and an impaired insulin response has been documented in them. To look for alternative mechanisms that could explain this intolerance, a glucose turnover using ...
    • Hormetic responses of thyroid hormone calorigenesis in the liver: Association with oxidative stress 
      Videla Cabrera, Luis (2010)
      Thyroid hormone (L-3,3',5-triiodothyronine, T3) exerts calorigenic effects by accelerating mitochondrial O2 consumption through transcriptional activation of respiratory genes, with consequent increased reactive oxygen ...
    • In situ rat brain and liver spontaneous chemiluminescence after acute ethanol intake 
      Boveris, Alberto; Llesuy, Susana; Azzalis, Ligia A.; Giavarotti, Leandro; Simon, Karin A.; Junqueira, Virginia; Porta, Eduardo A.; Videla Cabrera, Luis; Lissi Gervaso, Eduardo A. (1997)
      The influence of acute ethanol administration on the oxidative stress status of rat brain and liver was assessed by in situ spontaneous organ chemiluminescence (CL). Brain and liver CL was significantly increased after ...
    • Kupffer cell-dependent signaling in thyroid hormone calorigenesis: Possible applications for liver preconditioning 
      Fernández, Virginia; Videla Cabrera, Luis (2009)
      Thyroid hormone (L-3,3′,5-triiodothyronine, T3) is important for the normal function of most tissues, with major actions on O2 consumption and metabolic rate. In the liver, these are due to (i) transcriptional activation ...
    • Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat ... 
      Dassonvalle, Jonatan; Díaz Castro, Francisco; Donoso Barraza, Camila; Sepúlveda, Carlos; Pino de la Fuente, Francisco; Pino, Pamela; Espinosa Escalona, Berta; Chiong Lay, Mario; Llanos Silva, Miguel; Troncoso Cotal, Rodrigo (MDPI, 2020)
      Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is associated with the development of obesity and metabolic syndrome. However, it is not understood if obesity alters the tissue glucocorticoid ...
    • Muscarinic receptors associated with cancer 
      Calaf, Gloria M.; Crispin, Leodan A.; Muñoz, Juan P.; Aguayo González, Francisco Renán; Bleak, Tammy C. (MDPI, 2022)
      Simple Summary Recently, cancer research has described the presence of the cholinergic machinery, specifically muscarinic receptors, in a wide variety of cancers due to their activation and signaling pathways associated ...
    • Redox regulation of thyroid hormone-induced Kupffer cell-dependent IκB-α phosphorylation in relation to ... 
      Fernández Arancibia, Virginia; Tapia Opazo, Gladys; Varela, Patricia; Videla Cabrera, Luis (2005)
      Thyroid hormone-induced calorigenesis promotes oxidative stress in the liver with higher respiratory burst activity in Kupffer cells, which could increase the expression of redox-sensitive genes. Our aim was to test the ...
    • Role of dietary alpha- and gamma-tocopherol from Rosa mosqueta oil in the prevention of alterations induced ... 
      Tapia Opazo, Gladys; Silva, David; Romero Palacios, Nalda; Pettinelli, Paulina; Dossi, Camila G.; Miguel, Manuel de; González Mañán, Daniel Alonso (Elsevier, 2018)
      Objective: The aim of this study was to evaluate the contribution of tocopherols present in Rosa mosqueta oil (RM) in the prevention of high-fat diet (HFD)-induced alterations. Methods: Male C57 BL/6 J mice (n = 9/group) ...
    • Targeting kupffer cells with antisense oligonucleotides 
      Ponnappa, Biddanda C.; Israel Jacard, Yedy (Frontiers in Bioscience, 2002)
      © 2002 Frontiers in Bioscience. All rights reserved.During proinflammatory reactions such as endotoxemia, ischemia-reperfusion and immune reactions, excessive amounts of cytokines and prostanoids are released resulting in ...
    • The metabolic dysfunction of white adipose tissue induced in mice by a high-fat diet is abrogated by ... 
      Illesca, Paola; Valenzuela, Rodrigo; Espinosa, Alejandra; Echeverría, Francisca; Soto Alarcón, Sandra A.; Ortiz, Macarena; Campos, Cristian; Vargas, Romina; Videla Cabrera, Luis (Royal Society of Chemistry, 2020)
      Background: Nutritional interventions are promising tools for the prevention of obesity. The n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) docosahexaenoic acid (DHA) modulates immune and metabolic responses while ...
    • Thyroid hormone activates rat liver adenosine 5-monophosphate-activated protein kinase: Relation to CaMKKβ, ... 
      Vargas, R.; Ortega, Y.; Bozo, V.; De Andrade, M.; Minuzzi, G.; Cornejo, P.; Fernández Arancibia, Virginia; Videla Cabrera, Luis (2013)
      AMP-activated protein kinase (AMPK) is a sensor of energy status supporting cellular energy homeostasis that may represent the metabolic basis for 3,3′,5-triiodo-L-thyronine (T3) liver preconditioning. Functionally transient ...
    • Thyroid hormone induced expression of the hepatic scaffold proteins sestrin2, beta Klotho, and FRS2 in ... 
      Videla Cabrera, Luis; Vargas, Romina; Riquelme, Barbara; Fernández, Javier; Fernández Arancibia, Virginia (Johann Ambrosius Barth Verlag Medizinverlage Heidelberg GMBH, 2018)
      Thyroid hormone (3,3', 5-triiodothyronine, T-3) accelerates energy metabolism in the liver through mechanisms involving upregulation of AMP-activated protein kinase (AMPK). This study aims to assess the influence of T-3 ...