Browsing by Subject "Pulmonary hypertension"

Now showing items 1-12 of 12

    • A model of pediatric end-stage lung failure in small lambs <20 kg 
      Carr, Benjamin D.; Poling, Clinton J.; Hala, Pavel; Cáceres Quiñones, Matías; Prater, Aaron R.; McLeod, Jennifer S.; Bartlett, Robert H.; Rojas-Peña, Álvaro; Hirschl, Ronald B. (Lippincott Williams & Wilkins, 2020)
      One in five children with end-stage lung failure (ESLF) die while awaiting lung transplant. No suitable animal model of ESLF exists for the development of artificial lung devices for bridging to transplant. Small lambs ...
    • Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with ... 
      Gabrielli, Luigi; Ocaranza, María Paz; Sitges, Marta; Kanacri, Andrés; Saavedra, Rodrigo; Sepúlveda, Pablo; Sepúlveda, Luis; Rossel, Víctor; Zagolin, Mónica; Verdejo, Hugo E.; Baraona, Fernando; Zalaquett Sepúlveda, Ricardo; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Blackwell, 2017)
      Background: Right atrium function and ventricular function have significant prognos-tic value in pulmonary arterial hypertension patients. Acute changes in right ventricu-lar synchrony and right atrium function postiloprost ...
    • Cinaciguat (BAY-582667) modifies cardiopulmonary and systemic circulation in chronically hypoxic and pulmonary ... 
      Beñaldo Fuentes, Felipe Augusto; Araya Quijada, Claudio Enrique; Ebensperger Darrouy, Germán; Herrera Videla, Emilio Augusto; Reyes, Roberto V.; Moraga, Fernando A.; Riquelme Herrera, Alexander Nathan; González Candia, Alejandro; Castillo Galán, Sebastián; Valenzuela, Guillermo J.; Serón Ferré, María Josefa; Llanos, Aníbal J. (Frontiers Media, 2022)
      Neonatal pulmonary hypertension (NPHT) is produced by sustained pulmonary vasoconstriction and increased vascular remodeling. Soluble guanylyl cyclase (sGC) participates in signaling pathways that induce vascular vasodilation ...
    • Effect of pulmonary hypertension in exercise tolerance in patients with chronic obstructive pulmonary ... 
      Torres Castro, Rodrigo; Gimeno-Santos, Elena; Vilaro, Jordi; Figuls, Marta Roque I.; Moisés, Jorge; Albert Barbera, Joan; Blanco, Isabel (European Respiratory Soc Journals, 2020)
    • Effects of Pulmonary Hypertension on Exercise Capacity in Patients With Chronic Obstructive Pulmonary Disease 
      Blanco, Isabel; Valeiro, Beatriz; Torres Castro, Rodrigo; Barberán García, Anael; Torralba, Yolanda; Moisés, Jorge; Sebastián, Laura; Osorio, Jeisson; Ríos, José; Gimeno Santos, Elena; Roca, Josep; Barbera, Joan A. (Elsevier, 2020)
      Introduction: The impact of pulmonary hypertension (PH) on exercise tolerance in chronic obstructive pulmonary disease (COPD) has not been fully elucidated. It is necessary to characterize pulmonary hemodynamics in patients ...
    • Exercise capacity in patients with pulmonary arterial hypertension: multicentric analysis of aerobic capacity ... 
      Blanco, I.; Torres Castro, R.; Gimeno Santos, E.; Moisés, Jorge; Coronel, M.; Sebastián, L.; Escribano Subías, P.; Barbera, J. (American Thoracic Society, 2020)
    • Mid-term follow-up of balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary ... 
      Sepúlveda, Pablo; Hameau, René; Backhouse, Christian; Charme, Gustavo; Pacheco, Francisco; Ramírez, Pablo A.; Fuensalida, Alberto J.; Quitral, Jorge; Martínez, Gonzalo; Martínez, José A. (Wiley, 2020)
      Objectives To describe the characteristics of patients who undergo balloon pulmonary angioplasty (BPA) for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) and report the mid-term outcomes. Background BPA ...
    • Pharmacological approaches in either intermittent or permanent hypoxia: A tale of two exposures 
      Herrera, E. A.; Farías, J. G.; Ebensperger Darrouy, Germán; Reyes, R. V.; Llanos, A. R.; Castillo, R. L. (Elsevier, 2015)
      Hypoxia induces several responses at cardiovascular, pulmonary and reproductive levels, which may lead to chronic diseases. This is relevant in human populations exposed to high altitude (HA), in either chronic continuous ...
    • Revisiting the role of TRP, orai, and ASIC channels in the pulmonary arterial response to hypoxia 
      Reyes, Roberto V.; Castillo Galán, Sebastián; Hernández, Ismael; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Llanos Mansilla, Jorge (Frontiers Media S.A., 2018)
      © 2018 Reyes, Castillo-Galán, Hernandez, Herrera, Ebensperger and Llanos. The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and proportionally contract as arterial PO2 decrease, and they ...
    • Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs 
      López, Nandy; Ebensperger Darrouy, Germán; Herrera Videla, Emilio; Reyes, Roberto V.; Calaf, Gloria; Cabello, Gertrudis; Moraga, Fernando; Benaldo, Felipe A.; Díaz, Marcela; Parer, Julian T.; Llanos Mansilla, Jorge (Amer Physiological Soc, 2016)
      Exposure to high-altitude chronic hypoxia during pregnancy may cause pulmonary hypertension in neonates, as a result of vasoconstriction and vascular remodeling. We hypothesized that susceptibility to pulmonary hypertension, ...
    • Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic ... 
      Navarrete, Álvaro; Chen, Zhuoming; Aranda, Pedro; Poblete, Daniel; Utrera, Andrés; García Herrera, Claudio; González Candia, Alejandro; Beñaldo, Felipe A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Herrera Videla, Emilio; Llanos, Aníbal J. (Frontiers Media, 2020)
      In this study, we assessed the effects of Atrial Natriuretic Peptide (ANP) and Cinaciguat, as experimental medicines to treat neonatal lambs exposed to chronic hypoxic conditions. To compare the different treatments, the ...
    • Systemic oxidative stress and endothelial dysfunction is associated with an attenuated acute vascular ... 
      Gabrielli, Luigi; Castro, Pablo F.; Godoy, Ivan; Mellado, Rosemarie; Bourge, Robert C.; Alcaíno Gálvez, Hernán Alejandro; Chiong Lay, Mario; Greig, Douglas; Verdejo, Hugo; Navarro, Mario; Lopez, Rafael; Toro, Barbra; Quiroga, Clara; Díaz Araya, Guillermo; Lavandero González, Sergio; Garcia, Lo (2011)
      Background: Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with ...