Browsing by Author "Sorsa, Timo"

Now showing items 1-9 of 9

    • Active MMP-8 quantitative test as an adjunctive tool for early diagnosis of periodontitis 
      Hernández Ríos, Marcela; Baeza Paredes, Mauricio Enrique; Raisanen, Ismo; Contreras Balbontín, Johanna; Tervahartiala, Taina; Chaparro, Alejandra; Sorsa, Timo; Hernández Ríos, Patricia (MDPI, 2021)
      Periodontitis is a host-mediated bacterial disease that affects the tooth attachment apparatus. Metalloproteinase-8 (MMP-8), a validated biomarker, could aid in clinical diagnosis. This study aimed to evaluate the diagnostic ...
    • Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic ... 
      Sorsa, Timo; Tervahartiala, Taina; Leppilahti, Jussi; Hernández Ríos, Emma; Gamonal Aravena, Jorge Antonio; Tuomainen, Anita M.; Lauhio, Anneli; Pussinen, Pirkko J.; Mäntylä, Päivi (Elsevier, 2011-02)
      Neutrophil collagenase or collagenase-2 (matrix metalloproteinase [MMP]-8) belongs to the collagenase subgroup of the MMP superfamily of calcium- and zinc-dependent neutral proteinases. MMP-8 is catalytically the most ...
    • Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods 
      Sorsa, Timo; Hernández Ríos, Emma; Leppilahti, Jussi; Munjal, S.; Netuschil, L.; Mäntylä, Päivi (John Wiley & Sons, 2010)
      OBJECTIVE: The aim of the study was to compare four methods for gingival crevicular fluid (GCF) matrix metalloproteinase (MMP)-8 detection. METHODS: Matrix metalloproteinase-8 levels from 20 GCF samples from two ...
    • Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an ... 
      Baeza Paredes, Mauricio; Garrido Flores, Carlos; Hernández Ríos, Patricia; Dezerega Piwonka, Andrea; García Sesnich, Jocelyn; Strauss Avendaño, Franz; Aitken Saavedra, Juan; Lesaffre, Emmanuel; Vanbelle, Sophie; Gamonal Aravena, Jorge Antonio; Brignardello Petersen, Romina; Tervahartiala, Taina; Sorsa, Timo; Hernández Ríos, Marcela (Wiley, 2016)
      AimThe aim of this study was to assess the levels and diagnostic accuracy of a set of potential biomarkers of periodontal tissue metabolism in gingival crevicular fluid (GCF) from patients with chronic periodontitis (CP) ...
    • Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen ... 
      Cavalla Ruiz, Ian; Osorio Alfaro, Constanza; Paredes, Rodolfo; Valenzuela Pedevila, María Antonieta; García Sesnich, Jocelyn; Sorsa, Timo; Tervahartiala, Taina; Hernández Ríos, Emma (Elsevier, 2015)
      Periodontitis is a highly prevalent infectious disease characterized by the progressive inflammatory destruction of tooth-supporting structures, leading to tooth loss. The underling molecular mechanisms of the disease ...
    • MMP activation in diagnostics of periodontitis and systemic inflammation 
      Sorsa, Timo; Mäntylä, Päivi; Tervahartiala, Taina; Pussinen, Pirkko J.; Gamonal Aravena, Jorge Antonio; Hernández Ríos, Emma (John Wiley & Sons A/S, 2011-09)
    • Oral rinse MMP-8 point-of-care immuno test identifies patients with strong periodontal inflammatory burden 
      Leppilahti, Jussi; Ahonen, M.-M.; Hernández Ríos, Emma; Munjal, S.; Netuschil, L.; Uitto, V.-J.; Sorsa, Timo; Mäntylä, Päivi (John Wiley, 2011)
      OBJECTIVE: To determine whether oral rinse matrix metalloproteinase (MMP)-8 levels, measured by three different methods, tissue inhibitor of matrix metalloprotease- 1 (TIMP-1) levels and elastase activity differentiat ...
    • Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial ... 
      Hernández Ríos, Emma; Sorsa, Timo; Obregón, Fabián; Tervahartiala, Taina; Valenzuela, María Antonieta; Pozo, Patricia; Dutzan Muñoz, Nicolás; Lesaffre, Emmanuel; Molas, Marek; Gamonal Aravena, Jorge Antonio (European Federation of Periodontology, 2009-12)
      Aim: Matrix metalloproteinases (MMP)-13 can initiate bone resorption and activate proMMP-9 in vitro, and both these MMPs have been widely implicated in tissue destruction associated with chronic periodontitis. We studied ...
    • Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental ... 
      Hernández Ríos, Emma; Gamonal Aravena, Jorge Antonio; Salo, T.; Tervahartiala, Taina; Hukkanen, M.; Tjäderhane, L.; Sorsa, Timo (John Wiley & Sons A/S, 2011-02)
      Background and Objective:  Matrix metalloproteinase-8 (MMP-8) is a central mediator in chronic periodontitis. Recently developed MMP-8-deficient mice show an impaired polymorphonuclear neutrophil response and more severe ...