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Ovarian function during puberty in girls with type 1 diabetes mellitus: Response to Leuprolide

Authordc.contributor.authorCodner Dujovne, Ethel 
Authordc.contributor.authorMook-Kanamori, Dennis es_CL
Authordc.contributor.authorBazaes Castillo, Rodrigo Antonio es_CL
Authordc.contributor.authorUnanue Morales, Nancy es_CL
Authordc.contributor.authorSovino, Hugo es_CL
Authordc.contributor.authorUgarte, Francisca es_CL
Authordc.contributor.authorAvila, Alejandra es_CL
Authordc.contributor.authorIñíguez Vila, Germán es_CL
Authordc.contributor.authorCassorla Goluboff, Fernando es_CL
Admission datedc.date.accessioned2007-05-17T17:11:57Z
Available datedc.date.available2007-05-17T17:11:57Z
Publication datedc.date.issued2005-07
Cita de ítemdc.identifier.citationJOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90 (7): 3939-3945 JUL 2005en
Identifierdc.identifier.issn0021-972X
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/127162
Abstractdc.description.abstractContext: An increased prevalence of polycystic ovary syndrome (PCOS) has been reported in adult women with type 1 diabetes mellitus (DM1). We investigated whether these hormonal abnormalities begin during puberty by evaluating the ovarian steroidogenic response to leuprolide acetate. Methods: We studied 56 adolescent girls with DM1 (aged 12.3 +/- 0.2 yr) and 64 healthy girls (C) (aged 11.9 +/- 0.2 yr) up to 2 yr post menarche, matched by age, body mass index, and pubertal development. We evaluated anthropometrical data and Ferriman-Gallway score and performed a leuprolide test (500 mu g sc) to study ovarian function. Ovarian volume was determined by transabdominal ultrasonography. Results: We found five DM1 but no C girls with abnormally located terminal hair (Fisher's exact, P < 0.05). Free androgen index increased throughout puberty in girls with DM1 (ANOVA, P < 0.0001), which was associated with a decrease in SHBG levels in girls with DM1 (ANOVA, P < 0.0001). Stimulated 17OH progesterone (17OHProg) increased throughout puberty only in girls with DM1 (ANOVA, P < 0.01). Girls with DM1 at Tanner stage 5 had higher stimulated LH to FSH ratio, testosterone, and 17OHProg levels than girls at Tanner stage 4. In contrast, in C girls the stimulated testosterone, 17OHProg, and LH to FSH ratio were similar at Tanner stages 4 and 5. Ovarian volumes and uterine length were larger in girls with DM1 (analysis of covariance, P < 0.05). Conclusions: These data suggest that patients with DM1 have differences in ovarian steroidogenic response to leuprolide, compared with C girls during puberty. Future studies in young women should clarify whether these findings are related to the pathogenesis of hyperandrogenism later in life.en
Lenguagedc.language.isoenen
Publisherdc.publisherENDOCRINE SOCen
Keywordsdc.subjectHORMONE-BINDING GLOBULINen
Títulodc.titleOvarian function during puberty in girls with type 1 diabetes mellitus: Response to Leuprolideen
Document typedc.typeArtículo de revistaen


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