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Ovarian function during puberty in girls with type 1 diabetes mellitus: Response to Leuprolide

Authordc.contributor.authorCodner Dujovne, Ethel 
Authordc.contributor.authorMook-Kanamori, Dennis es_CL
Authordc.contributor.authorBazaes Castillo, Rodrigo Antonio es_CL
Authordc.contributor.authorUnanue Morales, Nancy es_CL
Authordc.contributor.authorSovino, Hugo es_CL
Authordc.contributor.authorUgarte, Francisca es_CL
Authordc.contributor.authorAvila, Alejandra es_CL
Authordc.contributor.authorIñíguez Vila, Germán es_CL
Authordc.contributor.authorCassorla Goluboff, Fernando es_CL
Cita de ítemdc.identifier.citationJOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM 90 (7): 3939-3945 JUL 2005en
Abstractdc.description.abstractContext: An increased prevalence of polycystic ovary syndrome (PCOS) has been reported in adult women with type 1 diabetes mellitus (DM1). We investigated whether these hormonal abnormalities begin during puberty by evaluating the ovarian steroidogenic response to leuprolide acetate. Methods: We studied 56 adolescent girls with DM1 (aged 12.3 +/- 0.2 yr) and 64 healthy girls (C) (aged 11.9 +/- 0.2 yr) up to 2 yr post menarche, matched by age, body mass index, and pubertal development. We evaluated anthropometrical data and Ferriman-Gallway score and performed a leuprolide test (500 mu g sc) to study ovarian function. Ovarian volume was determined by transabdominal ultrasonography. Results: We found five DM1 but no C girls with abnormally located terminal hair (Fisher's exact, P < 0.05). Free androgen index increased throughout puberty in girls with DM1 (ANOVA, P < 0.0001), which was associated with a decrease in SHBG levels in girls with DM1 (ANOVA, P < 0.0001). Stimulated 17OH progesterone (17OHProg) increased throughout puberty only in girls with DM1 (ANOVA, P < 0.01). Girls with DM1 at Tanner stage 5 had higher stimulated LH to FSH ratio, testosterone, and 17OHProg levels than girls at Tanner stage 4. In contrast, in C girls the stimulated testosterone, 17OHProg, and LH to FSH ratio were similar at Tanner stages 4 and 5. Ovarian volumes and uterine length were larger in girls with DM1 (analysis of covariance, P < 0.05). Conclusions: These data suggest that patients with DM1 have differences in ovarian steroidogenic response to leuprolide, compared with C girls during puberty. Future studies in young women should clarify whether these findings are related to the pathogenesis of hyperandrogenism later in life.en
Publisherdc.publisherENDOCRINE SOCen
Títulodc.titleOvarian function during puberty in girls with type 1 diabetes mellitus: Response to Leuprolideen
Document typedc.typeArtículo de revistaen

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