| Author | dc.contributor.author | Rey, Rodolfo A. | |
| Author | dc.contributor.author | Codner Dujovne, Ethel | es_CL |
| Author | dc.contributor.author | Iñíguez Vila, Germán | es_CL |
| Author | dc.contributor.author | Bedecarrás, Patricia | es_CL |
| Author | dc.contributor.author | Trigo, Romina | es_CL |
| Author | dc.contributor.author | Okuma, Cecilia | es_CL |
| Author | dc.contributor.author | Gottlieb, Silvia | es_CL |
| Author | dc.contributor.author | Bergadá, Ignacio | es_CL |
| Author | dc.contributor.author | Campo, Stella M. | es_CL |
| Author | dc.contributor.author | Cassorla Goluboff, Fernando | es_CL |
| Admission date | dc.date.accessioned | 2007-06-05T15:24:25Z | |
| Available date | dc.date.available | 2007-06-05T15:24:25Z | |
| Publication date | dc.date.issued | 2005-11 | |
| Cita de ítem | dc.identifier.citation | JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM | en |
| Identifier | dc.identifier.issn | 0021-972X | |
| Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/127280 | |
| Abstract | dc.description.abstract | Testicular dysfunction was observed in 57.1% and androgen end- organ defects in 7.2% of patients with hypospadias associated with cryptorchidism, micropenis, or ambiguous genitalia. In the remaining 35.7%, the disorder was idiopathic. The presence of ambiguous genitalia predicted the existence of testicular or end- organ dysfunction with 81.8% specificity. Isolated hypospadias was associated in 14.8% of patients with testicular dysfunction and in 6.5% of cases with end- organ defects; in 78.7% of cases, the condition was idiopathic. The occurrence of isolated hypospadias ruled out the existence of testicular or end- organ disorders with 80.0% sensitivity. Altogether our data indicate that the risk for the existence of an underlying testicular or end- organ dysfunction is low in patients with isolated hypospadias ( odds ratio, 0.13; 95% confidence interval, 0.05 - 0.36; P < 0.001).
Conclusions: Boys with isolated hypospadias are more likely to have normal endocrine testicular and androgen end- organ functions, suggesting that transient disruption of morphogenetic events in early fetal life may be the predominant underlying cause. | en |
| Lenguage | dc.language.iso | en | en |
| Publisher | dc.publisher | ENDOCRINE SOC. | en |
| Keywords | dc.subject | MULLERIAN-INHIBITING SUBSTANCE | en |
| Título | dc.title | Low risk of impaired testicular sertoli and Leydig cell functions in boys with isolated hypospadias | en |
| Document type | dc.type | Artículo de revista | |
