Author | dc.contributor.author | Silva, Manuel A. | es_CL |
Author | dc.contributor.author | Quera Pino, Rodrigo | es_CL |
Author | dc.contributor.author | Valenzuela Escobar, Jorge | es_CL |
Author | dc.contributor.author | Salim, Sa’ad Y. | es_CL |
Author | dc.contributor.author | Söderholm, Johan D. | es_CL |
Author | dc.contributor.author | Perdue, Mary H. | |
Admission date | dc.date.accessioned | 2010-01-19T15:10:13Z | |
Available date | dc.date.available | 2010-01-19T15:10:13Z | |
Publication date | dc.date.issued | 2008-07 | |
Cita de ítem | dc.identifier.citation | DIGESTIVE DISEASES AND SCIENCES, Volume: 53, Issue: 7, Pages: 1917-1928, 2008 | en_US |
Identifier | dc.identifier.issn | 0163-2116 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/128254 | |
Abstract | dc.description.abstract | We investigated myeloid-dendritic cell (DC)
marker and Toll-like receptor (TLR)-2 and 4 distributions
in ileal samples from Crohn’s disease (CD) patients
(n = 14) and controls (n = 13). In controls, no TLR-2+
cells were observed, and higher numbers of TLR-4+ and
DC-SIGN+ cells (P\0.01) were detected in ileal samples
when compared versus colonic tissues. In non-inflamed CD
ileum, TLR-4+ and DC-SGN+ cells were depleted from
superficial areas of the villus, and a significant CD1a+ cell
infiltration (P\0.01) was observed when compared to
ileal controls and non-inflamed colonic CD samples. In
inflamed CD ileum, DC-SIGN+, CD1a+, TLR-4+ and few
TLR-4+DC-SIGN+ cells were detected as well as CD83
depletion. No correlation between TLR-2 and DC markers
was detected in CD samples. A unique distribution of
myeloid-DC markers characterized the CD ileum. Also, the
presence of significant amounts of ileal CD1a+ cells may
provide a relevant DC-mediated mechanism for antigen
recognition in the pathogenesis of CD. | en_US |
Lenguage | dc.language.iso | en | en_US |
Publisher | dc.publisher | SPRINGER | en_US |
Keywords | dc.subject | Crohn’s disease | en_US |
Título | dc.title | Dendritic Cells and Toll-Like Receptors 2 and 4 in the Ileum of Crohn's disease patients | en_US |
Document type | dc.type | Artículo de revista | |