| Abstract | dc.description.abstract | Background Knowledge about the practical consequences
of the nutritional status of Fe, Zn, and Cu and inflammation
in obesity is limited. The objective of this study was to
evaluate changes on trace element status and their potential
associations with selected inflammation parameters in
patients after Roux-en-Y gastric bypass (RYGBP).
Methods Sixty-three women (mean age, 36.9±9.2 years,
body mass index, 43.8±4.3 kg/m2) were evaluated at
baseline and 6 months after RYGBP. Anthropometric
(weight, waist circumference), body composition (fat mass
and fat-free mass), dietary (nutrient intakes), and metabolic
and inflammation (glucose, insulin, HOMA-IR, adiponectin,
HDL-cholesterol, LDL-cholesterol, triglycerides, hs-
CRP, leukocytes, polymorphonuclear neutrophils (PMN))
parameters were determined in addition to selected indices
of Fe, Zn, and Cu status.
Results All but one (HDL-cholesterol) metabolic and
inflammation parameters had significant differences when compared before and after RYGBP. Hemoglobin, serum
ferritin, the size of the rapidly exchangeable zinc pool, and
plasma copper decreased after RYGBP. Plasma and hair
zinc, as well as zinc protoporphyrin increased. The change
in Hb was significantly associated (p<0.05) to the change
in leukocytes (r=0.33) and adiponectin (r=−0.44). Zinc
protoporphyrin change was associated to the change in
PMN (r=0.32) and HDL-cholesterol (r=−0.29). No other
associations between the changes of the rest of Fe, Zn, and
Cu parameters with the changes of any of the metabolic and
inflammation parameters were observed.
Conclusion RYGBP produced significant weight and fat
mass losses, with improvement of metabolic and inflammation
parameters. Iron, zinc, and copper status were
impaired after the surgery. | es_CL |
