El hábito de fumar se asocia a baja concentración plasmática de hormona antimülleriana en mujeres infértiles
Author
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Fuentes García, Frans
Author
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Escalona, Javier
es_CL
Author
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Céspedes Pino, Pablo
es_CL
Author
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Repetto, Victoria
es_CL
Author
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Iñíguez Vila, Germán
es_CL
Admission date
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2014-01-27T12:47:34Z
Available date
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2014-01-27T12:47:34Z
Publication date
dc.date.issued
2013
Cita de ítem
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Rev Med Chile 2013; 141: 23-27
en_US
Identifier
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https://repositorio.uchile.cl/handle/2250/129172
General note
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Artículo de publicación ISI
en_US
Abstract
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Background: Smoking may hamper female fertility, probably modifying ovarian
reserve. Antimüllerian hormone (AMH) is an accurate marker for ovarian reserve.
Aim: To look for an association between smoking status and plasma AMH concentration.
Patients and Methods: A cohort of 141 infertile women in a university
setting in Santiago, Chile was studied. Demographic and smoking data, including
the number of cigarettes smoked during the last week, were collected. A blood sample
was obtained and kept frozen until determination of AMH by ELISA and follicle
stimulating hormone (FSH) and estradiol at day three of the menstrual cycle, by
radioimmunoanalysis. Results: Thirty two participants smoked (23%). There were
no significant differences in age, parity, body mass index, causes of infertility and day
three FSH and estradiol between smokers and nonsmokers. According to a regression
analysis, there was a significant decrease in AMH concentration with age and active
cigarette smoking. A drop in AMH of -0.189 ng/mL with a unitary change in age and
a decrease of -2.29 ng/mL when everything else remains constant, except the smoking
status, were established (p < 0.001 and r2 = 0.134). However, no dose response was
observed when the number of cigarettes smoked during the last week were introduced
in the model. Furthermore, no significant association of plasma AMH with day three
plasma FSH and estradiol concentrations was observed. Conclusions: Cigarette smoking
is associated with decreased AMH plasma concentrations among infertile women.
However there was no dose response relationship. The mechanisms underlying this
association are unknown and further investigation is required.