Respiratory syncytial virus infection and recurrent wheezing in Chilean infants: A genetic background?
Author
dc.contributor.author
Tapia, Lorena I.
Author
dc.contributor.author
Ampuero Llanos, Sandra
es_CL
Author
dc.contributor.author
Palomino Montenegro, María Angélica
es_CL
Author
dc.contributor.author
Luchsinger Farías, Vivian
es_CL
Author
dc.contributor.author
Aguilar, Nelson
es_CL
Author
dc.contributor.author
Ayarza, Eliana
es_CL
Author
dc.contributor.author
Mamani, Rossana
es_CL
Author
dc.contributor.author
Larrañaga Jiménez, Carmen
es_CL
Admission date
dc.date.accessioned
2014-03-12T20:37:26Z
Available date
dc.date.available
2014-03-12T20:37:26Z
Publication date
dc.date.issued
2013
Cita de ítem
dc.identifier.citation
Infection, Genetics and Evolution 16 (2013) 54–61
en_US
Identifier
dc.identifier.issn
doi 10.1016/j.meegid.2012.12.030
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/129312
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
dc.description.abstract
Respiratory syncytial virus (RSV) infection has been associated to recurrent wheezing, but pathogenic
mechanisms are unclear. Interleukin-4/Interleukin-13 (IL-4/IL-13) pathway is involved in both conditions.
A common host genetic susceptibility may exist in patients whom RSV will trigger severe illness
and those who develop recurrent wheezing.
Objective: To assess, by a candidate-gene approach, whether genetic polymorphisms in IL-4/IL-13 pathway
are associated with RSV infection severity and its outcome in Chilean children.
A cohort of 118 RSV-infected infants was analyzed and followed for one year. Severity of acute infection
and later recurrent wheezing were characterized. Alleles and genotypes frequencies were determined for
two SNP in each of the genes IL-4, IL-13 and IL-4Ra. Association tests and interaction analyses were performed.
Enrollment included 60 moderate and 58 severe cases. Two SNP were found associated to severity during
acute infection in IL-4Ra gene (Gln551Arg, Ile50Val). The follow up was completed in 71% of patients (84/
118). Later recurrent wheezing was 54% in severe group, versus 31% in moderate cases (p = 0.035). In relation
to outcome, allele Ile50 in IL-4Ra was more frequent in patients with moderate disease and no
wheezing outcome. A common protector genotype is proposed for Chilean children: IL-4Ra Ile/Ile.
Conclusion: Genetic variations in the host are associated to infection severity and outcome. A common
genetic background might be influencing both pathologies.