Vascular mineralocorticoid receptor and blood pressure regulation
Author
dc.contributor.author
Tarjus, Antoine
Author
dc.contributor.author
Amador, Cristian
Author
dc.contributor.author
Michea Acevedo, Luis
Author
dc.contributor.author
Jaisser, Frédéric
Admission date
dc.date.accessioned
2015-08-11T12:48:28Z
Available date
dc.date.available
2015-08-11T12:48:28Z
Publication date
dc.date.issued
2015
Cita de ítem
dc.identifier.citation
Current Opinion in Pharmacology 2015, 21:138–144
en_US
Identifier
dc.identifier.issn
1471-4892
Identifier
dc.identifier.other
DOI: 10.1016/j.coph.2015.02.004
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/132555
General note
dc.description
Artículo de publicación ISI
en_US
Abstract
dc.description.abstract
The mineralocorticoid receptor (MR) is a major regulator of
blood pressure by modulating sodium balance and blood
volume in the distal nephron. The discovery of MR expression in
both endothelial and vascular smooth muscle cells a decade
ago raised questions about its role in the vascular wall and its
involvement in blood pressure regulation. In vitro and in vivo
pharmacological studies have shown that vascular MR is
involved in several vascular properties such as extracellular
matrix remodeling, inflammation and vascular reactivity. In this
review, we focus on recent advances obtained using transgenic
model with cell-specific modulation of the expression MR in
endothelium or smooth muscle and their impact on blood
pressure
en_US
Patrocinador
dc.description.sponsorship
FP7-funded COST-ADMIRE BM1301
network, the C09S01 ECOS-CONICYT