Mechanisms of long-term weight regain in patients undergoing sleeve gastrectomy
Author
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Alvarez, Verónica
Author
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Carrasco Naranjo, Fernando
Author
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Cuevas, Ada
Author
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Valenzuela, Barbara
Author
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Muñoz, Giselle
Author
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Ghiardo, Daniela
Author
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Burr, Maria
Author
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Lehmann, Yael
Author
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Leiva, Maria
Author
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Berry, Marcos
Author
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Maluenda, Fernando
Admission date
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2016-06-16T22:52:11Z
Available date
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2016-06-16T22:52:11Z
Publication date
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2016
Cita de ítem
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Nutrition 32 (2016) 303–308
en_US
Identifier
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DOI: 10.1016/j.nut.2015.08.023
Identifier
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https://repositorio.uchile.cl/handle/2250/138933
General note
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Artículo de publicación ISI
en_US
Abstract
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Objectives: Weight regain after bariatric surgery may be associated with behavioral, metabolic, or mechanical factors alone or in combination. The aim of this study was to investigate which factors are related to weight regain in the long-term after sleeve gastrectomy (SG).
Methods: A retrospective case-control study with 40 patients undergoing SG (32 women, 8 men; age 42.9 +/- 10.7 y; preoperative body mass index 35 +/- 2.8 kg/m(2)), was performed. Patients were grouped according percentile->50% (cases) or <50% (controls)-of weight regain (%WR cutoff: 25% of weight loss). Weight history, anthropometry, glucose, insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), thyroid-stimulating hormone, resting energy expenditure, body composition, dietary survey, psychological test, and physical activity were recorded. Residual gastric capacity was estimated using a radiologic method.
Results (median [p25-p75]): The evaluation was conducted 38.5 mo (34-41 mo) after SG. Percent weight regain ranged from 2.7% to 129.2% (25.4% [13-37.1]). Patients in the higher %WR group had a greater residual gastric volume (252.7 +/- 108.4 versus 148.5 +/- 25.3; P < 0.05) and the estimated volume was significantly correlated with %WR (r = 0.673; P = 0.023). Significantly higher body mass index (P = 0.001), resting energy expenditure (P = 0.04), fasting insulin (P = 0.01), and HOMA-IR (P = 0.02) were observed in the higher %WR group. A higher fat intake and a trend toward higher total energy intake were observed in the group with greater %WR. Clinical or borderline levels of anxiety were more frequently observed in the higher %WR group (70% versus 30%; P = 0.01).
Conclusions: Results from the present study demonstrated that the most important factor associated with long-term weight regain after SG was residual gastric volume. Additional prospective studies with larger numbers of patients are necessary to confirm our results.
en_US
Patrocinador
dc.description.sponsorship
grant DI, Academic Department, Clinica Las Condes; Covidien