Deleterious Effect of p-Cresol on Human Colonic Epithelial Cells Prevented by Proanthocyanidin-Containing Polyphenol Extracts from Fruits and Proanthocyanidin Bacterial Metabolites
Author | dc.contributor.author | Wong, Ximena | |
Author | dc.contributor.author | Carrasco Pozo, Catalina | |
Author | dc.contributor.author | Escobar, Elizabeth | |
Author | dc.contributor.author | Navarrete Wallace, Paola | |
Author | dc.contributor.author | Blachier, Francois | |
Author | dc.contributor.author | Andriamihaja, Mireille | |
Author | dc.contributor.author | Lang, Annaig | |
Author | dc.contributor.author | Tome, Daniel | |
Author | dc.contributor.author | Cires, María José | |
Author | dc.contributor.author | Pastene, Edgar | |
Author | dc.contributor.author | Gotteland, Martin | |
Admission date | dc.date.accessioned | 2016-10-26T20:19:11Z | |
Available date | dc.date.available | 2016-10-26T20:19:11Z | |
Publication date | dc.date.issued | 2016 | |
Cita de ítem | dc.identifier.citation | Journal of Agricultural and Food Chemistry Volumen: 64 Número: 18 Páginas: 3574-3583 May 2016 | es_ES |
Identifier | dc.identifier.other | 10.1021/acs.jafc.6b00656 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/141015 | |
Abstract | dc.description.abstract | The protective effect of proanthocyanidin-containing polyphenol extracts from apples, avocados, cranberries, grapes, or proanthocyanidin microbial metabolites was evaluated in colonic epithelial cells exposed to p-cresol, a deleterious compound produced by the colonic microbiota from L-tyrosine. In HT29 Glc(-/+) cells, p-cresol significantly increased LDH leakage and decreased ATP contents, whereas in Caco-2 cell monolayers, it significantly decreased the transepithelial electrical resistance and increased the paracellular transport of FITC-dextran. The alterations induced by p-cresol in HT29 Glc(-/+) cells were prevented by the extracts from cranberries and avocados, whereas they became worse by extracts from apples and grapes. The proanthocyanidin bacterial metabolites decreased LDH leakage, ameliorating cell viability without improving intracellular ATP. All of the polyphenol extracts and proanthocyanidin bacterial metabolites prevented the p-cresol-induced alterations of barrier function. These results suggest that proanthocyanidin-containing polyphenol extracts and proanthocyanidin metabolites likely contribute to the protection of the colonic mucosa against the deleterious effects of p-cresol. | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | Amer Chemical Society | es_ES |
Source | dc.source | Journal of Agricultural and Food Chemistry | es_ES |
Keywords | dc.subject | p-cresol | es_ES |
Keywords | dc.subject | Mitochondria | es_ES |
Keywords | dc.subject | Proanthocyanidins | es_ES |
Keywords | dc.subject | Colonic | es_ES |
Título | dc.title | Deleterious Effect of p-Cresol on Human Colonic Epithelial Cells Prevented by Proanthocyanidin-Containing Polyphenol Extracts from Fruits and Proanthocyanidin Bacterial Metabolites | es_ES |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | es_ES |
Cataloguer | uchile.catalogador | laj | es_ES |
Indexation | uchile.index | Artículo de publicación ISI | es_ES |
Files in this item
This item appears in the following Collection(s)
-
Artículos de revistas
Artículos de revistas