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The fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origin

Authordc.contributor.authorPhan, Tung Gia 
Authordc.contributor.authorda Costa, Antonio Charlys 
Authordc.contributor.authorValle Mendoza, Juana del 
Authordc.contributor.authorBucardo-Rivera, Filemon 
Authordc.contributor.authorNordgren, Johan 
Authordc.contributor.authorO'Ryan Gallardo, Miguel 
Authordc.contributor.authorDeng, Xutao 
Authordc.contributor.authorDelwart, Eric 
Cita de ítemdc.identifier.citationArch Virol (2016) 161:959–966es_ES
Abstractdc.description.abstractViral metagenomics of feces collected from 58 Peruvian children with unexplained diarrhea revealed several small circular ssDNA genomes. Two genomes related to sequences previously reported in feces from chimpanzees and other mammals and recently named smacoviruses were characterized and then detected by PCR in 1.7 % (1/58) and 19 % (11/58) of diarrheal samples, respectively. Another three genomes from a distinct small circular ssDNA viral group provisionally called pecoviruses encoded Cap and Rep proteins with < 35 % identity to those in related genomes reported in human, seal, porcine and dromedary feces. Pecovirus DNA was detected in 15.5 % (9/58), 5.9 % (3/51) and 3 % (3/100) of fecal samples from unexplained diarrhea in Peru, Nicaragua and Chile, respectively. Feces containing these ssDNA genomes also contained known human enteric viral pathogens. The cellular origins of these circular ssDNA viruses, whether human cells, ingested plants, animals or fungal foods, or residents of the gut microbiome, are currently unknown.es_ES
Patrocinadordc.description.sponsorshipNHLBI R01 HL105770 Sao Paulo Research Foundation (FAPESP) 2014/05211-2 2012/03417-7es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceArchives of Virologyes_ES
Títulodc.titleThe fecal virome of South and Central American children with diarrhea includes small circular DNA viral genomes of unknown origines_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile