Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies
Author
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Lord, Phillip
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Spiering, Rachel
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Aguillón Gutiérrez, Juan Carlos
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Anderson, Amy E.
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Appel, Silke
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Benítez Ribas, Daniel
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Ten Brinke, Anja
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Broere, Femke
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Cools, Nathalie
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Cuturi, María Cristina
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Diboll, Julie
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Geissler, Edward K.
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Giannoukakis, Nick
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Gregori, Silvia
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van Ham, S. Marieke
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Lattimer, Staci
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Marshall, Lindsay
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Harry, Rachel A.
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Hutchinson, James A.
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Isaacs, John D.
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Joosten, Irma
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van Kooten, Cees
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López Díaz de Cerio, Ascension
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Nikolic, Tatjana
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Oral, Haluk Barbaros
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Sofronic Milosavljevic, Ljiljana
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Ritter, Thomas
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Riquelme, Paloma
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Thomson, Angus W.
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Trucco, Massimo
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Vives Pi, Marta
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Martínez Cáceres, Eva M.
Author
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Hilkens, Catharien M.
Admission date
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2017-03-01T20:45:39Z
Available date
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2017-03-01T20:45:39Z
Publication date
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2016
Cita de ítem
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PEERJ. Volumen: 4 Número de artículo: e2300
es_ES
Identifier
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10.7717/peerj.2300
Identifier
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https://repositorio.uchile.cl/handle/2250/142899
Abstract
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Cellular therapies, with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way, MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.