n-3 LCPUFA in the reversal of hepatic steatosis: the role of ACOX and CAT-1
Author
dc.contributor.author
Tapia, G. S.
Author
dc.contributor.author
González Manan, D.
Author
dc.contributor.author
D'Espessailles Tapia, Amanda
Author
dc.contributor.author
Dossi, C. G.
Admission date
dc.date.accessioned
2017-03-06T16:32:42Z
Available date
dc.date.available
2017-03-06T16:32:42Z
Publication date
dc.date.issued
2016
Cita de ítem
dc.identifier.citation
Grasas y Aceites. Volumen: 67 Número: 2 Número de artículo: e134
es_ES
Identifier
dc.identifier.other
10.3989/gya.0886152
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/143001
Abstract
dc.description.abstract
The aim of this study was to investigate the roles of the Acyl co-enzyme A oxidase (ACOX), carnitine acyl transferase I (CAT-1) and activating protein 1 (AP-1) in the reversal of hepatic steatosis with dietary change and n-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation. Male C57BL/6J mice were given either a control diet (CD) or a high fat diet (HFD) for 12 weeks, and then continued with the CD or CD plus n-3 LCPUFA for eight weeks. After this period, body and adipose visceral tissue weight were analyzed and liver samples were taken to measure ACOX, CAT-1 and c-jun levels. The dietary change from HFD to a norm caloric diet plus n-3 LCPUFA supplementation significantly reduced liver steatosis and adipose tissue: body weight ratio, along with an increase in the hepatic ACOX and CAT-1 levels and normalization of AP-1 expression that could favor the fatty acid beta-oxidation over lipogenesis and regulate inflammation. These results provide new data on the enzymatic metabolism underlying dietary change to a norm caloric diet plus n-3 LCPUFA supplementation.