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A local innate immune response against Trypanosoma cruzi in the human placenta: The epithelial turnover of the trophoblast

Authordc.contributor.authorLiempi Manquel, Ana 
Authordc.contributor.authorCastillo Varela, Christian 
Authordc.contributor.authorCarrillo Werner, Ileana 
Authordc.contributor.authorMuñoz Clavijo, Lorena 
Authordc.contributor.authorDroguett Ossa, Daniel 
Authordc.contributor.authorGalanti Garrone, Norbel 
Authordc.contributor.authorMaya Arango, Juan 
Authordc.contributor.authorKemmerling Weis, Ulrike 
Cita de ítemdc.identifier.citationMicrobial Pathogenesis 99 (2016) 123e129es_ES
Abstractdc.description.abstractCongenital Chagas disease, caused by Trypanosoma cruzi, is partially responsible for the progressive globalization of Chagas disease despite of its low transmission rate. The probability of congenital transmission depends on complex interactions between the parasite, the maternal and fetus/newborn immune responses and placental factors, being the latter the least studied one. During transplacental transmission, the parasite must cross the placental barrier where the trophoblast, a continuous renewing epithelium, is the first tissue to have contact with the parasite. Importantly, the epithelial turnover is considered part of the innate immune system since pathogens, prior to cell invasion, must attach to the surface of cells. The trophoblast turnover involves cellular processes such as proliferation, differentiation and apoptotic cell death, all of them are induced by the parasite. In the present review, we analyze the current evidence about the trophoblast epithelial turnover as a local placental innate immune response. (C) 2016 Elsevier Ltd. All rights reservedes_ES
Patrocinadordc.description.sponsorshipERANET-LAC grant ELAC2014/HID-0328 ENL027/16 "Fondo Nacional de Desarrollo Cientifico y Tecnologico" (FONDECYT, Chile) 1120230 1130189 1130113es_ES
Publisherdc.publisherAcademic Presses_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceMicrobial Pathogenesises_ES
Keywordsdc.subjectCongenital Chagas-Diseasees_ES
Keywordsdc.subjectHuman Villous Trophoblastes_ES
Keywordsdc.subjectChorionic Villies_ES
Títulodc.titleA local innate immune response against Trypanosoma cruzi in the human placenta: The epithelial turnover of the trophoblastes_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile