Nodal signalling and asymmetry of the nervous system
Author
dc.contributor.author
Signore Ahumada, Iskra
Author
dc.contributor.author
Palma González, Karina
Author
dc.contributor.author
Concha Nordemann, Miguel
Admission date
dc.date.accessioned
2017-12-21T14:02:29Z
Available date
dc.date.available
2017-12-21T14:02:29Z
Publication date
dc.date.issued
2016
Cita de ítem
dc.identifier.citation
Phil. Trans. R. Soc. B 371: 20150401
es_ES
Identifier
dc.identifier.issn
0962-8436
Identifier
dc.identifier.other
10.1098/rstb.2015.0401
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/146255
Abstract
dc.description.abstract
The role of Nodal signalling in nervous system asymmetry is still poorly understood. Here, we review and discuss how asymmetric Nodal signalling controls the ontogeny of nervous system asymmetry using a comparative developmental perspective. A detailed analysis of asymmetry in ascidians and fishes reveals a critical context-dependency of Nodal function and emphasizes that bilaterally paired and midline-unpaired structures/organs behave as different entities. We propose a conceptual framework to dissect the developmental function of Nodal as asymmetry inducer and laterality modulator in the nervous system, which can be used to study other types of body and visceral organ asymmetries. Using insights from developmental biology, we also present novel evolutionary hypotheses on how Nodal led the evolution of directional asymmetry in the brain, with a particular focus on the epithalamus. We intend this paper to provide a synthesis on how Nodal signalling controls left-right asymmetry of the nervous system
es_ES
Patrocinador
dc.description.sponsorship
Chilean National Commission for Scientific and Technological Research
FONDECYT 1161274
FONDAP 15150012
ACT1402
Chilean Millennium Science Initiative
P09-015-F