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Search for Primary Infection by Pneumocystis carinii in a Cohort of Normal, Healthy Infants

Authordc.contributor.authorVargas Munita, Sergio 
Authordc.contributor.authorHughes, Walter T. 
Authordc.contributor.authorSantolaya de Pablo, María Elena 
Authordc.contributor.authorUlloa, Ana V. 
Authordc.contributor.authorPonce, Carolina A. 
Authordc.contributor.authorCabrera, Cecilia E. 
Authordc.contributor.authorCumsille, Francisco 
Authordc.contributor.authorGigliotti, Francis 
Cita de ítemdc.identifier.citationClinical Infectious Diseases 2001; 32:855–61es_ES
Abstractdc.description.abstractTo determine whether Pneumocystis carinii is associated with clinical illness in the competent host, 107 normal, healthy infants were enrolled in a 2-year prospective cohort study in Chile. P. carinii was identified by specific stains and nested-deoxyribonucleic acid (DNA) amplification of the large subunit mitochondrial ribosomal ribonucleic acid gene of P. carinii f. sp. hominis, and seroconversion was assessed by enzyme-linked immunosorbent assay of serum samples drawn every 2 months. P. carinii DNA was identified in nasopharyngeal aspirates obtained during episodes of mild respiratory infection in 24 (32%) of 74 infants from whom specimens were available for testing. Three (12.5%) of those 24 infants versus 0 of 50 infants who tested negative for P. carinii had apnea episodes. Seroconversion developed in 67 (85%) of 79 infants who remained in the study by 20 months of age and occurred in the absence of any symptoms of disease in 14 (20.8%). The study indicates that P. carinii DNA can be frequently detected in healthy infants, and it raises the hypothesis that they may be an infectious reservoir of P. carinii in the community. Further investigation is needed to identify whether P. carinii causes overt respiratory disease in infants.es_ES
Patrocinadordc.description.sponsorshipThis work was supported in part by Fondo Nacional de Desarrollo Científico y Tecnolo´gico (FONDECYT research grant 1960940), Santiago, Chile; the St. Jude International Outreach Program and American-Lebanese- Syrian–Associated Charities, St. Jude Children’s Research Hospital, Memphis; and the National Institutes of Health (grant AI-23302).es_ES
Publisherdc.publisherUnic Chicago Presses_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceClinical Infectious Diseaseses_ES
Títulodc.titleSearch for Primary Infection by Pneumocystis carinii in a Cohort of Normal, Healthy Infantses_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile