The axonal endoplasmic reticulum: one organelle many functions in development, maintenance, and plasticity
Author
dc.contributor.author
Luarte, Alejandro
Author
dc.contributor.author
Cornejo, Victor Hugo
Author
dc.contributor.author
Bertin, Francisca
Author
dc.contributor.author
Gallardo, Javiera
Author
dc.contributor.author
Couve Correa, Andrés
Admission date
dc.date.accessioned
2018-07-27T16:15:31Z
Available date
dc.date.available
2018-07-27T16:15:31Z
Publication date
dc.date.issued
2018
Cita de ítem
dc.identifier.citation
Developmental Neurobiology, 78 (3): 181-208
es_ES
Identifier
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10.1002/dneu.22560
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/150382
Abstract
dc.description.abstract
The endoplasmic reticulum (ER) is highly conserved in eukaryotes and neurons. Indeed, the localization of the organelle in axons has been known for nearly half a century. However, the relevance of the axonal ER is only beginning to emerge. In this review, we discuss the structure of the ER in axons, examining the role of ER-shaping proteins and highlighting reticulons. We analyze the multiple functions of the ER and their potential contribution to axonal physiology. First, we examine the emerging roles of the axonal ER in lipid synthesis, protein translation, processing, quality control, and secretory trafficking of transmembrane proteins. We also review the impact of the ER on calcium dynamics, focusing on intracellular mechanisms and functions. We describe the interactions between the ER and endosomes, mitochondria, and synaptic vesicles. Finally, we analyze available proteomic data of axonal preparations to reveal the dynamic functionality of the ER in axons during development. We suggest that the dynamic proteome and a validated axonal interactome, together with state-of-the-art methodologies, may provide interesting research avenues in axon physiology that may extend to pathology and regeneration.
es_ES
Patrocinador
dc.description.sponsorship
Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
1170307
3170887
3160725
Iniciativa Cientifica Milenio (ICM)
P09-015-F