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Acción de flavonoides sobre la conversión de ácidos grasos poliinsaturados de cadena larga a partir de ácidos grasos esenciales

Authordc.contributor.authorReyna G, Sixto 
Authordc.contributor.authorValenzuela Báez, Rodrigo 
Authordc.contributor.authorVillanueva, María Elena 
Cita de ítemdc.identifier.citationRev Chil Nutr 2018; 45(2): 153-162.es_ES
Abstractdc.description.abstractEpidemiological and clinical studies have reported multiple benefits from the intake of Long Chain Polyunsaturated Fatty Acids n-3 (LC-PUFA n-3), EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid); however, overexploitation of marine sources limits current and future availability. The alpha-linolenic acid (ALA) is a metabolic precursor of PUFAs n-3-LC, therefore its consumption is an alternative to be considered. However, the conversion of ALA to EPA and DHA is not efficient. On other hand, antioxidants such as flavonoids increase serum and tissue concentration of PUFA LC n-3, although the underlying mechanisms are not fully elucidated. The effect of PUFAs and flavonoids on metabolism PUFAs n-3 LC. to modulate transcription factors such as peroxisome proliferators alpha receptor (PPAR-alpha), the sterol regulatory element-binding protein, (SREBP 1) and genic expression of fatty acid desaturase enzymes delta 5 (Delta 5) and delta 6 (Delta 6) was explored. Other hypotheses that could explain the increase of n-3 PUFAs were also included such as antioxidant action, exerted by flavonoids and their metaboliteses_ES
Publisherdc.publisherSociedad Chilena de Bromatología y Toxicologíaes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceRevista Chilena de Nutriciónes_ES
Keywordsdc.subjectDesaturase Delta 5 and Delta 6es_ES
Títulodc.titleAcción de flavonoides sobre la conversión de ácidos grasos poliinsaturados de cadena larga a partir de ácidos grasos esencialeses_ES
Title in another languagedc.title.alternativeAction of flavonoids on conversion of long chain polyunsaturated fatty acids from essential fatty acidses_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile