Utilidad pronóstica del PET/CT en cáncer de páncreas
Author
dc.contributor.author
Ladrón de Guevara, David
Author
dc.contributor.author
Pavez, Gonzalo
Author
dc.contributor.author
Zapata, Jaime
Author
dc.contributor.author
Romero, Claudio
Author
dc.contributor.author
Tapia, Valezka
Author
dc.contributor.author
Buckel, Erwin
Author
dc.contributor.author
Ferrario, Mario
Admission date
dc.date.accessioned
2018-11-26T12:56:03Z
Available date
dc.date.available
2018-11-26T12:56:03Z
Publication date
dc.date.issued
2018-04
Cita de ítem
dc.identifier.citation
Rev Med Chile 2018; 146: 413-421
es_ES
Identifier
dc.identifier.issn
0034-9887
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/152859
Abstract
dc.description.abstract
Background: Pancreatic cancer is the tenth most prevalent cancer in world, and represents the fourth cause of cancer death. It has a five year-survival of 5%. Aim: To assess the prognostic value of PET/CT in pancreatic cancer. Material and Methods: Sixty-nine patients with pancreatic adenocarcinoma who underwent staging F-18-fluorodeoxyglucose (FDG) PET/CT between December 2008 and July 2016 were selected. Gender, age, body-mass index, laboratory tests (Ca 19-9, hemoglobin, erythrocyte sedimentation rate, liver enzymes, lactate dehydrogenase), histological differentiation of tumor, American Joint Committee on Cancer (AJCC) stage, size and F-18-FDG uptake (maximal standardized uptake value [SUVmax]) of the primary tumor, nodal involvement and distant metastasis detected by PET/CT were registered. Survival was assessed using Kaplan-Meier curves, Log Rank test and Cox multivariable analysis. Results: Mortality was 66.7%, during a mean observation time of 18 months (range 20 days-66 months). Curative surgery, lack of metastases detected by PET/CT, histologically well differentiated tumors, and SUVmax <= 4.3 were significantly associated with a better specific survival, determined by the Log Rank test. Histological differentiation was the only variable that had a statistically significant prognostic value in the multivariable analysis. Conclusions: The detection of distant metastases and the intensity of primary tumor F-18-FDG uptake during PET/CT provide useful prognostic information in pancreatic cancer patients.