Nitrite determination as a stable metabolite of nitric oxide in synovial fluid of equine metacarpophalangeal joint Determinación de nitrito como metabolito estable del óxido nítrico en el líquido sinovial de articulación metacarpofalángica equina
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The striking feature of osteoarthritis (OA) is fibrilation and loss of articular cartilage. Nitric oxide (NO•) has been involved as an important biological mediator of OA and its production is significantly higher in OA cartilage. NO• suppresses cartilagenous matrix synthesis and induces condrocytes apoptosis in articular cartilage. The NO• production was indirectly determined by measuring nitrite by Griess reaction. Nitrite concentration of synovial fluid was compared in different equine metacarpophalangic joint conditions. Joint classification and age determination were carried out by macroscopic examination. It was considered a normal joint group NN (n = 47) the one without any visual damage of articular structures. The damaged groups considered a) a group with a congestive synovial membrane without cartilage damage NA (n = 25), b) a group with damaged cartilage and normal synovial membrane AN (n=23) and c) a group with damaged cartilage and congestive synovial membrane AA (n = 15).
Artículo de publicación SCOPUS