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Chagas disease: Present status of pathogenic mechanisms and chemotherapy

Authordc.contributor.authorMaya Arango, Juan 
Authordc.contributor.authorOrellana, Myriam 
Authordc.contributor.authorFerreira, Jorge 
Authordc.contributor.authorKemmerling Weis, Ulrike 
Authordc.contributor.authorLópez Muñoz, Rodrigo 
Authordc.contributor.authorMorello, Antonio 
Admission datedc.date.accessioned2019-01-29T15:36:35Z
Available datedc.date.available2019-01-29T15:36:35Z
Publication datedc.date.issued2010
Cita de ítemdc.identifier.citationBiological Research, Volumen 43, Issue 3, 2018, Pages 323-331
Identifierdc.identifier.issn07176287
Identifierdc.identifier.issn07169760
Identifierdc.identifier.other10.4067/S0716-97602010000300009
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/161781
Abstractdc.description.abstractThere are approximately 7.8 million people in Latin America, including Chile, who suffer from Chagas disease and another 28 million who are at risk of contracting it. Chagas is caused by the flagellate protozoan Trypanosoma cruzi. It is a chronic disease, where 20%-30% of infected individuals develop severe cardiopathy, with heart failure and potentially fatal arrhythmias. Currently, Chagas disease treatment is more effective in the acute phase, but does not always produce complete parasite eradication during indeterminate and chronic phases. At present, only nifurtimox or benznidazole have been proven to be superior to new drugs being tested. Therefore, it is necessary to find alternative approaches to treatment of chronic Chagas. The current treatment may be rendered more effective by increasing the activity of anti-Chagasic drugs or by modifying the host's immune response. We have previously shown that glutathione synthesis inhibition increases nifurtimox and benznidazole activity.
Lenguagedc.language.isoen
Publisherdc.publisherSociety of Biology of Chile
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBiological Research
Keywordsdc.subjectChagas disease
Keywordsdc.subjectChemotherapy
Keywordsdc.subjectNifurtimox
Keywordsdc.subjectProstaglandins
Keywordsdc.subjectTrypanosoma cruzi
Títulodc.titleChagas disease: Present status of pathogenic mechanisms and chemotherapy
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile