Effect of ethanol ingestion on renal regulation of water and electrolytes
Author
dc.contributor.author
Vidal, Rodrigo
Author
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Thielemann, Lilian
Author
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Olea, Juan
Author
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Munoz,
Author
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Cereceda, D.
Author
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Orellana,
Admission date
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2019-01-29T17:15:48Z
Available date
dc.date.available
2019-01-29T17:15:48Z
Publication date
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1998
Cita de ítem
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Archives of Medical Research, Volumen 29, Issue 3, 2018, Pages 209-218
Identifier
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01880128
Identifier
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https://repositorio.uchile.cl/handle/2250/163330
Abstract
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Ethanol may alter the homeostasis of water and electrolytes before the occurrence of liver damage able to explain these disorders. How the kidney may become involved in water diuresis or sodium and potassium retention has not been well elucidated. During the last decade, an increasing body of evidence has guided interest toward the relevance of the biochemical basis of ethanol-induced injury to the kidney. Multiple functional abnormalities of renal tubules may be associated with ethanol-induced changes in membrane composition and lipid peroxidation of these epithelial cells. Ethanol interferes with the carrier function by decreasing (Na + K)-ATPase activity, but this activity is enhanced by chronic exposure. Recently, it was reported that ethanol oxidation by the kidney is favored in chronic ethanol-treated rats, thereby suggesting a pathogenic role for acetaldehyde in the nephrotoxic effect of ethanol ingestion. Also, increased reactive oxygen species, partly generated from acetaldehy