Regional brain blood flow and cerebral hemispheric oxygen consumption during acute hypoxaemia in the Ilama fetus
Author
dc.contributor.author
Llanos Mansilla, Jorge
Author
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Riquelme, Raquel A.
Author
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Sanhueza, Emilia M.
Author
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Herrera Videla, Emilio
Author
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Cabello, Gertrudis
Author
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Giussani, Dino A.
Author
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Parer, Julian T.
Admission date
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2019-01-29T17:51:12Z
Available date
dc.date.available
2019-01-29T17:51:12Z
Publication date
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2002
Cita de ítem
dc.identifier.citation
Journal of Physiology, Volumen 538, Issue 3, 2018, Pages 975-983
Identifier
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00223751
Identifier
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10.1113/jphysiol.2001.013230
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/163533
Abstract
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Unlike fetal animals of lowland species, the llama fetus does not increase its cerebral blood flow during an episode of acute hypoxaemia. This study tested the hypothesis that the fetal llama brain maintains cerebral hemispheric O2 consumption by increasing cerebral O2 extraction rather than decreasing cerebral oxygen utilisation during acute hypoxaemia. Six llama fetuses were surgically instrumented under general anaesthesia at 217 days of gestation (term ca 350 days) with vascular and amniotic catheters in order to carry out cardiorespiratory studies. Following a control period of 1 h, the llama fetuses underwent 3 × 20 min episodes of progressive hypoxaemia, induced by maternal inhalational hypoxia. During basal conditions and during each of the 20 min of hypoxaemia, fetal cerebral blood flow was measured with radioactive microspheres, cerebral oxygen extraction was calculated, and fetal cerebral hemispheric O2 consumption was determined by the modified Fick principle. During hypoxa