The role of neuropeptide Y in the ovine fetal cardiovascular response to reduced oxygenation
Author
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Sanhueza, Emilia M.
Author
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Johansen-Bibby, Anja A.
Author
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Fletcher, A. J W
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Riquelme, Raquel A.
Author
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Daniels, Alejandro J.
Author
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Serón Ferré, María
Author
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Gaete, Cristián R.
Author
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Carrasco, Jorge E.
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Llanos Mansilla, Jorge
Author
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Giussani, Dino A.
Admission date
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2019-01-29T17:51:56Z
Available date
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2019-01-29T17:51:56Z
Publication date
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2003
Cita de ítem
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Journal of Physiology, Volumen 546, Issue 3, 2018, Pages 891-901
Identifier
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00223751
Identifier
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10.1113/jphysiol.2002.034488
Identifier
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https://repositorio.uchile.cl/handle/2250/163620
Abstract
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This study investigated the role of neuropeptide Y (NPY) in mediating cardiovascular responses to reduced oxygenation in the late gestation ovine fetus by: (1) comparing the effects on the cardiovascular system of an exogenous infusion of NPY with those elicited by moderate or severe reductions in fetal oxygenation; and (2) determining the effect of fetal I.V. treatment with a selective NPY-Y1 receptor antagonist on the fetal cardiovascular responses to acute moderate hypoxaemia. Under general anaesthesia, 14 sheep fetuses (0.8-0.9 of gestation) were surgically prepared with vascular and amniotic catheters. In 5 of these fetuses, a Transonic flow probe was also implanted around a femoral artery. Following at least 5 days of recovery, one group of fetuses (n = 9) was subjected to a 30 min treatment period with exogenous NPY (17 μg kg-1 bolus plus 0.85 μg kg-1 min-1 infusion). In this group, fetal blood pressure and heart rate were monitored continuously and the distribution of the fetal