Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr
Author
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Corvalán R, Alejandro
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Akiba, Suminori
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Valenzuela Bravo, María Teresa
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Cumsille G, Miguel Angel
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Koriyama, Chihaya
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Argandoña C, Jorge
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Backhouse E, Claudia
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Bal C, Matilde
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Mena U, Fernando
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Palma V, Mariana
Author
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Eizuru, Yoshito
Admission date
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2019-01-29T17:57:00Z
Available date
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2019-01-29T17:57:00Z
Publication date
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2005
Cita de ítem
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Revista Medica de Chile, Volumen 133, Issue 7, 2018, Pages 753-760
Identifier
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00349887
Identifier
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07176163
Identifier
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https://repositorio.uchile.cl/handle/2250/163906
Abstract
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Background: Mortality caused by cardial gastric cancer in Chile, is increasing. Previously we demonstrated an association between Epstein Barr virus and this specific location of gastric cancer. Aim: To perform a clinical and molecular characterization of cardial gastric cancer associated to Epstein Barr virus. Material and methods: Epstein Barr virus was identified in 93 cardial gastric tumors, by in situ hybridization. Clinical and pathological features, survival and expression of p53 and c-erbB2 were compared between tumors with or without the presence of the virus. Results: Twenty two (23.6%) tumors expressed Epstein Barr virus. No difference in sex or age of patients with tumors positive or negative for the virus was observed. Epstein Barr positive tumors had a tendency to have a higher frequency of Bormann III endoscopic appearance and a lower frequency of p53 accumulation (p=0.06). Five years survival was 67% and 42% of tumors positive and negative for the presence of the virus,
Clinical and molecular features of cardial gastric cancer associated to Epstein Barr virus Características clínico-moleculares del cáncer gástrico cardial asociado al virus Epstein Barr