Hyperhomocysteinemia in healthy young men and elderly men with normal serum folate concentration is not associated with poor vascular reactivity or oxidative stress
Author
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Hirsch Birn, Sandra
Author
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Ronco Macchiavello, Ana María
Author
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Vásquez, Marcela
Author
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Maza Cave, María Pía de la
Author
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Garrido, Argelia
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Barrera, Gladys
Author
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Gattas, Vivien
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Glasinovic, Andrea
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Leiva, Laura
Author
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Bunout Barnett, Daniel
Admission date
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2019-01-29T17:57:08Z
Available date
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2019-01-29T17:57:08Z
Publication date
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2004
Cita de ítem
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Journal of Nutrition, Volumen 134, Issue 7, 2018, Pages 1832-1835
Identifier
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00223166
Identifier
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https://repositorio.uchile.cl/handle/2250/163936
Abstract
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The mechanism by which homocysteine (Hcy) causes endothelial dysfunction is probably mediated by oxidative stress. The aim of this study was to evaluate the effect of oxidative stress on endothelial function in young and elderly hyperhomocysteinemic (HHcy) men. A total of 35 HHcy (Hcy > 15 μmol/L), young (n = 15; 20-40 y) and elderly men (n = 20; > 65 y) and 33 normohomocysteinemic (NHcy; controls) young (n = 14) and elderly (n = 19) men (Hcy < 13 μmol/L), without classic cardiovascular risk factors were recruited. Serum Hcy, folate, and vitamin B-12, whole-blood glutathione, plasma total antioxidants status, TBARS, and 8-F2α isoprostanes were determined. Noninvasive ultrasound measurements of endothelium-dependent (EDVR) and -independent dilatation (EIVR) were performed. EDVR, EIVR, and markers of oxidative stress did not differ among the groups. Folate concentrations were higher in elderly than in young men (P < 0.001), independent of Hcy concentrations. Vitamin B-12 concentrations w
Hyperhomocysteinemia in healthy young men and elderly men with normal serum folate concentration is not associated with poor vascular reactivity or oxidative stress