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Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion

Authordc.contributor.authorPettinelli, Paulina 
Authordc.contributor.authorDel Pozo, Talía 
Authordc.contributor.authorAraya, Julia 
Authordc.contributor.authorRodrigo, Ramón 
Authordc.contributor.authorAraya, A. Verónica 
Authordc.contributor.authorSmok Sahid, Gladys 
Authordc.contributor.authorCsendes Juhasz, Attila 
Authordc.contributor.authorGutierrez, Luis 
Authordc.contributor.authorVargas Rojas, Jorge Antonio 
Authordc.contributor.authorKorn Bruzzone, Owen 
Authordc.contributor.authorMaluenda, Fernando 
Authordc.contributor.authorDiaz, Juan C. 
Authordc.contributor.authorRencoret, Guillermo 
Authordc.contributor.authorBraghetto Miranda, Italo 
Authordc.contributor.authorCastillo, Jaime 
Authordc.contributor.authorPoniachik Teller, Jaime 
Cita de ítemdc.identifier.citationBiochimica et Biophysica Acta - Molecular Basis of Disease, Volumen 1792, Issue 11, 2018, Pages 1080-1086
Abstractdc.description.abstractSterol receptor element-binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptor-α (PPAR-α) mRNA expression was assessed in liver as signaling mechanisms associated with steatosis in obese patients. Liver SREBP-1c and PPAR-α mRNA (RT-PCR), fatty acid synthase (FAS) and carnitine palmitoyltransferase-1a (CPT-1a) mRNA (real-time RT-PCR), and n-3 long-chain polyunsaturated fatty acid (LCPUFA)(GLC) contents, plasma adiponectin levels (RIA), and insulin resistance (IR) evolution (HOMA) were evaluated in 11 obese patients who underwent subtotal gastrectomy with gastro-jejunal anastomosis in Roux-en-Y and 8 non-obese subjects who underwent laparoscopic cholecystectomy (controls). Liver SREBP-1c and FAS mRNA levels were 33% and 70% higher than control values (P < 0.05), respectively, whereas those of PPAR-α and CPT-1a were 16% and 65% lower (P < 0.05), respectively, with a significant 62% enhancement in the SREBP-1c/PPAR-α ratio. Liver n-3 LCPUFA levels were 53% lower in ob
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceBiochimica et Biophysica Acta - Molecular Basis of Disease
Keywordsdc.subjectInsulin resistance
Keywordsdc.subjectLiver steatosis
Keywordsdc.subjectPeroxisome proliferator activated receptor-α
Keywordsdc.subjectSterol receptor element binding protein-1c
Títulodc.titleEnhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile